Phenotype molding of stromal cells in the lung tumor ... - Nature
2018年7月9日 · By comparing with matching non-malignant lung samples, we reveal a highly complex TME that profoundly molds stromal cells. We identify 52 stromal cell subtypes, including novel...
Phenotype molding of stromal cells in the lung tumor ... - PubMed
By comparing with matching non-malignant lung samples, we reveal a highly complex TME that profoundly molds stromal cells. We identify 52 stromal cell subtypes, including novel subpopulations in cell types hitherto considered to be homogeneous, as well as transcription factors underlying their heterogeneity.
Stromal–immune cell crosstalk fundamentally alters the lung ...
Stromal cells can perform functions classically attributed to immune cells, providing immunomodulatory functions and educating local immune cells within the lung. Communication between immune and stromal cells provides mutual support for the persistence of both cell types.
Lung mesenchymal stromal cells influenced by Th2 cytokines …
2021年10月27日 · Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Here we find that lung mesenchymal stromal cells (LMSCs) at pre-metastatic...
Lung mesenchymal stromal cells influenced by Th2 cytokines …
2021年10月27日 · Here we find that lung mesenchymal stromal cells (LMSCs) at pre-metastatic stage possess potent metastasis-promoting activity. RNA-seq reveals an upregulation of complement 3 (C3) in those LMSCs. C3 is found to promote neutrophil recruitment and the formation of neutrophil extracellular traps (NETs), which facilitate cancer cell metastasis to ...
Mesenchymal stromal cells facilitate resolution of pulmonary …
2023年7月3日 · Tiny regulatory RNAs found within membrane-bound vesicles released by fat-derived stem/stromal cells help to resolve lung scarring in a mouse model of pulmonary fibrosis.
Fibroblastic reticular cells generate protective intratumoral T cell ...
2024年11月19日 · Here, we show that CCL19-expressing fibroblastic reticular cells (FRCs) generate interconnected T cell environments (TEs) in human non-small cell lung cancer, including tertiary lymphoid structures and T cell tracks.
Mesenchymal stromal cells promote the formation of lung cancer ...
5 天之前 · Background Patient-derived lung cancer organoids (PD-LCOs) demonstrate exceptional potential in preclinical testing and serve as a promising model for the multimodal management of lung cancer. However, certain lung cancer cells derived from patients exhibit limited capacity to generate organoids due to inter-tumor or intra-tumor variability. To overcome this limitation, we have created an in ...
Mesenchymal stromal cell-based therapy in lung diseases; from …
Recent studies demonstrated that mesenchymal stem cells (MSCs) are important for the cell-based therapy of diseased or injured lung due to their immunomodulatory and regenerative properties as well as limited side effects in experimental animal models.
The Role of Lung Resident Mesenchymal Stromal Cells in the …
2023年2月7日 · Mesenchymal stromal/stem cells are multipotent adult cells that can be extracted from numerous tissues, including the lungs. Lung-resident MSCs (LR-MSCs) are localized to perivascular spaces where they act as important regulators of pulmonary homeostasis, mediating the balance between lung injury/damage and repair processes.
- 某些结果已被删除