Exosomal miRNA-mediated intercellular communications and ...
2023年8月21日 · These miRNA-loaded exosomes orchestrate vital processes such as the control of dendritic cell development, maturation, and function, as well as the polarization of macrophages. In the context of colitis, exosomal miRNAs derived from regulatory T cells effectively suppress Th1 cells, illustrating the profound impact of miRNAs as crucial ...
The microRNA regulatory landscape of MSC-derived exosomes: a …
2018年1月23日 · Here we microRNA (miRNA)-profiled MSC exosomes and conducted a network analysis to identify the dominant biological processes and pathways modulated by exosomal miRNAs. At a system level,...
Exosomes as miRNA Carriers: Formation–Function–Future
The rapidly changing understanding of exosomes’ formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.
Exosomal microRNAs derived from mesenchymal stem cells: …
2020年9月11日 · MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are widespread in eukaryotic cells, especially in mesenchymal stem cells (MSCs). MSCs are used for tissue regeneration, and also exert paracrine, anti-inflammatory and immunomodulatory effects.
Comparison of miRNA transcriptome of exosomes in three …
2023年9月11日 · Our study provides sets of comparative transcriptomic data of cellular mRNA and exosomal miRNA from three categories of human tissue with three individual biological controls in studies of iPSCs...
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
2015年2月1日 · Mature miRNAs are sorted into exosomes via four potential modes: (1) nSMase2-dependent pathway; (2) miRNA motif and sumoylated hnRNPs-dependent pathway; The sumoylated hnRNP family protein recognizes the GGAG motif in the 3′ portion of the miRNA sequence and guides specific miRNAs to be packed into exosomes.
Frontiers | The Role of Exosomes and Exosomal MicroRNA in ...
2021年1月11日 · Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane bilayer, secreted by most cells in the body. They carry various molecules, including proteins, lipids, mRNA, and other RNA species, such as long non-coding RNA, circular RNA, and microRNA (miRNA). miRNAs are the most numerous cargo molecules in the exosome.
Exosome and exosomal microRNA: trafficking, sorting, and function
In this review, we will introduce the origin and the trafficking of exosomes between cells, display current research on the sorting mechanism of exosomal miRNAs, and briefly describe how exosomes and their miRNAs function in recipient cells. Finally, we will discuss the potential applications of these miRNA-containing vesicles in clinical settings.
Exosomal MiRNA Therapy for Central Nervous System Injury …
4 天之前 · Exos have a lipid bilayer structure similar to the parent cells, which can effectively penetrate various physiological barriers in the body and promote communication between cells. ... Wang B, Chen Y (2019) Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats. Brazilian J Med Biol Res = Revista ...
Exosomes as miRNA Carriers: Formation–Function–Future - MDPI
2016年12月2日 · The rapidly changing understanding of exosomes’ formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for …
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