Science | 于洪涛/白晓辰组合作报道人类粘连蛋白三维结构 - 知乎
为了克服粘连蛋白构象高度柔性的问题，研究人员对复合物样品进行了系统性地尝试和优化，最终获得稳定构象的粘连蛋白，NIPBL与72个碱基对双链DNA复合物的电镜结构。 粘连蛋 …
Cryo-EM structure of the human cohesin-NIPBL-DNA complex | Science …
2020年5月14日 · Using cryo–electron microscopy (cryo-EM), we determined the structure of human cohesin bound to its loader NIPBL and DNA at medium resolution. Cohesin and NIPBL …
Different NIPBL requirements of cohesin-STAG1 and cohesin …
2023年3月10日 · Here we have examined the effect of reducing NIPBL levels on the behavior of the two cohesin variants carrying STAG1 or STAG2 by combining a flow cytometry assay to …
NIPBL - Wikipedia
Nipped-B-like protein (NIPBL), also known as SCC2 or delangin is a protein that in humans is encoded by the NIPBL gene. [5] . NIPBL is required for the association of cohesin with DNA …
Cryo-EM structure of the human cohesin-NIPBL-DNA complex
2020年6月26日 · Using cryo-electron microscopy (cryo-EM), we determined the structure of human cohesin bound to its loader NIPBL and DNA at medium resolution. Cohesin and NIPBL …
Q6KC79 - UniProt
Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed: 22628566, PubMed: …
人源cohesin-NIPBL-DNA复合物结构获解析 - 科学网
2020年5月13日 · Using cryo-electron microscopy, we determine the structure of human cohesin bound to its loader NIPBL and DNA at medium resolution. Cohesin and NIPBL interact …
NIPBL Gene - GeneCards | NIPBL Protein | NIPBL Antibody
2024年12月25日 · NIPBL (NIPBL Cohesin Loading Factor) is a Protein Coding gene. Diseases associated with NIPBL include Cornelia De Lange Syndrome 1 and Cornelia De Lange …
Nucleotide dependent interface switching of NIPBL (A
In the nucleotide free state (''X''), NIPBL interacts via its nose with the hinge. Bending moves the hinge together with NIPBL to the SMC3-head. Upon ATP-binding (''A''), the body of NIPBL...
DNA binding by cohesin and NIPBL C . (A) Structure of the cohesin-NIPBL …
(A) Structure of the cohesin-NIPBL C -DNA complex, with protein subunits shown in cartoon representation and the EM map of DNA shown as gray surface. (B) Interface between DNA …