2016年2月26日 · Nalorphine is a mixed opioid agonist–antagonist. It acts at two opioid receptors—at the mu receptor it has antagonistic effects, and at the kappa receptors it exerts high-efficacy agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.

Nalorphine is a narcotic antagonist that is used to reverse respiratory depression from narcotic overdose. It has been used either alone or in combination with meperidine or morphine during labor to reduce neonatal /respiratory/ depression. Nalorphine has also been given to the newborn to prevent neonatal asphyxia. /Former/

Nalorphine is a synthetic opioid that produces kappa receptor agonist and mu receptor antagonist effects. Nalorphine is used most commonly to reverse the effects of the mu receptor agonists (see Table 26-1).

Nalorphine is an opioid antagonist with some properties similar to those of naloxone. In addition, it possesses some agonist properties. It reverses severe opioid-induced respiratory depression, but may exacerbate respiratory depression such as that induced by ethanol or other non-opioid central depressants.

An early antagonist of most depressant and stimulatory effects of morphine and related narcotic analgesics; precipitates severe withdrawal symptoms in morphine addicts, and counteracts the respiratory depression produced by morphine and related compounds; when administered in the absence of narcotics, nalorphine has mildly analgesic and ...

Nalorphine is a mixed opioid agonist–antagonist. It acts at two opioid receptors—at the mu receptor it has antagonistic effects, and at the kappa receptors it exerts high-efficacy agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence. Cl.

The ensuing pharmacological studies of the effects of nalorphine and nalorphine + diverse opioid agonists resulted in complex outcomes thoroughly reviewed contemporaneously by the renowned clinical pharmacologist Dr. Louis Lasagna.

Nalorphine inhibits the cholinesterases of mouse brain, bovine erythrocytes and horse serum. It acts on mu-, k- and sigma-opioid receptors. Nalorfin by virtue of the agonistic effect has an analgesic effect but to a much lesser extent than morphine.

Nalorphine (INN; Lethidrone, Nalline), also known as N-allyl-normorphine, is a mixed opioid agonist–antagonist. It acts at two opioid receptors, at the mu receptor it has antagonistic effects and at the kappa receptors it exerts high-efficacy agonistic characteristics.

Know about technical details of Nalorphine Hydrochloride like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com.