The nucleocapsid (N) protein is a protein that packages the positive-sense RNA genome of coronaviruses to form ribonucleoprotein structures enclosed within the viral capsid. [2] [3] The N protein is the most highly expressed of the four major coronavirus structural proteins. [2]

Like other coronaviruses, the nucleocapsid (N) protein is one of the most crucial structural components of SARS-CoV-2. This protein shares 90% homology with the severe acute respiratory syndrome coronavirus N protein, implying functional significance.

2021年3月29日 · The SARS-CoV-2 nucleocapsid (N) protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that underlie this process are poorly understood.

2021年6月10日 · Like other coronaviruses, the nucleocapsid (N) protein is one of the most crucial structural components of SARS-CoV-2. This protein shares 90% homology with the severe acute respiratory syndrome coronavirus N protein, implying functional significance.

The kit has been verified by high purity SARS-CoV-2 (2019-nCoV) Nucleocapsid / N Protein (Cat# 40588-V08B) recombinant protein. It can recognize recombinant SARS-CoV Nucleocapsid / N Protein (His Tag) (Cat# 40143-V08B), but no react with recombinant MERS-CoV Nucleoprotein / NP protein (His Tag) (Cat# 40068-V08B).

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and ...

2023年1月10日 · The SARS-CoV-2 nucleocapsid (N) protein plays an important role in the coronavirus life cycle, and participates in various vital activities after virus invasion. It has attracted a large amount of attention for vaccine and drug development.

Nucleocapsid protein is the major constituent of a viral nucleocapsid. It is capable of associating with itself and with the genome, thus packaging the genome inside a closed cavity. In some viruses, nucleocapsid protein may also be assisted by other viral cofactors to form the capsid.

2020年9月11日 · Nucleocapsid (N) protein, which is the major structural component of the virion and is involved in viral replication, assembly and immune regulation, plays key roles in the viral life cycle. Here, we solved the crystal structures of the N‐ and C‐terminal domains (N‐ NTD and N‐ CTD ) of SARS ‐CoV‐2 N protein, at 1.8 and 1.5 Å ...

The nucleocapsid phosphoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV N protein) packages the viral genome into a helical ribonucleocapsid (RNP) and plays a fundamental role during viral self-assembly. It is a protein with multifarious activities.