Myofibroblasts have been identified as a significant contributor to this scarring. While the differentiation of fibroblasts into myofibroblasts is well-recognized as essential for wound healing and tissue repair, the mechanisms underlying the macrophage-myofibroblast transition (MMT) remain largely unexplored.
了解详细信息：Myofibroblasts have been identified as a significant contributor to this scarring. While the differentiation of fibroblasts into myofibroblasts is well-recognized as essential for wound healing and tissue repair, the mechanisms underlying the macrophage-myofibroblast transition (MMT) remain largely unexplored.
onlinelibrary.wiley.com/doi/10.1002/cbin.70002Macrophages play a pivotal role in skin wound healing, with M1(classically activated) and M2 (alternatively activated) macrophages exhibiting distinct but complementary functions.
biosignaling.biomedcentral.com/articles/10.1186/s1…The demarcation between mouse and human tissue was confirmed by immunostaining for mouse- and human-specific collagen, which revealed boundaries between mouse and human skin (fig. S12A). ... including CD9 + SPP1 + ARG1 + wound healing macrophages, CCR7 + migratory ... Autophagy inhibition facilitates wound closure partially dependent on the YAP ...
www.science.org/doi/10.1126/scitranslmed.adt6387The presence of pro-inflammatory M1 macrophages(CD80 positive cells) that at the wound bed over an extended period is considered an indication of delayed wound healing [34]. Thus, we evaluated the presence of M1 macrophages in the wound site implanted with G1, G2, G3 skin constructs.
www.sciencedirect.com/science/article/pii/S014181…Wound healing, a physiological process, involves several different types of cells, from immune cells to non-immune cells, including mesenchymal stromal/stem cells (MSC), and their interactions. Immune cells including macrophages, neutrophils, dendritic cells (DC), innate lymphoid cells (ILC), natural killer (NK) cells, and B and T lymphocytes participate in wound healing by secreting various ...
link.springer.com/article/10.1007/s12015-025-1084…Macrophage‐to‐Myofibroblast Transition Contributes to …
2025年2月13日 · Myofibroblasts have been identified as a significant contributor to this scarring. While the differentiation of fibroblasts into myofibroblasts is well-recognized as essential for wound healing and tissue repair, the mechanisms underlying the macrophage-myofibroblast …
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2025年1月29日 · Macrophages play a pivotal role in skin wound healing, with M1(classically activated) and M2 (alternatively activated) macrophages exhibiting distinct but complementary …
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Macrophages play a critical role in the wound healing process and can differentiate into two distinct phenotypes: the pro-inflammatory M1 phenotype and the anti-inflammatory M2 …