2023年4月5日 · Aging is associated with a decline in the regenerative potential of stem cells. In recent years, several clinical trials have been launched in order to evaluate the efficacy of mesenchymal stem cell interventions to slow or reverse …

The Standardization Guide of Stem Cell Antiaging Technology refers to sources of human autograft or allograft SCs that are cultured in vitro and then locally injected into specific parts of the human body or administered via intravenous infusion into the human body.

2018年1月10日 · Stem cells in combination with anti-aging genes make a complex and protective shield, which stand against the eroding effects of aging. Increased wear and tear of the stem cells, as well as Klotho deficiency, is expected to heavily increase cellular damage and accelerate the process of aging.

2022年4月5日 · Acein, dopamine-releasing peptide, promoted the adoptive infusion of NK cells in effectively eliminating SNCs in a variety of tissues and reduced local and systemic SASPs in aging mice but...

2017年10月12日 · Allo-hMSCs are safe and immunologically tolerated in aging frailty patients. Improvements in functional and immunologic status suggest that ongoing clinical development of cell-based therapy is warranted for frailty.

Core Tip: Mesenchymal stem cells (MSCs) exhibit promising anti-aging properties by targeting the underlying mechanisms of aging, including chronic inflammation, cellular senescence, and oxidative stress. Through their regenerative potential, immunomodulatory abilities, and secretome production, MSCs contribute to tissue repair and rejuvenation.

2024年9月20日 · Stem cells secrete components such as paracrine factors, extracellular vesicles, and exosomes which have been shown to have anti-inflammatory, anti-aging, reconstruction and wound healing potentials in many in vitro and in vivo models.

In this review article, we examine several mechanisms that are believed to contribute to the aging-related dysfunction of stem cells associated with diseases of the immune system, cardiac tissue, neuronal system, articular cartilage, and skeletal muscle.

2025年2月4日 · A large body of evidence suggests that mesenchymal stromal cells (MSCs) are able to respond rapidly to the cytokine milieu following systemic infusion. This encounter has the potential to dictate their therapeutic efficacy (also referred to as licensing). MSCs are able to rapidly react to cellular damage by migrating to the inflamed tissue and ultimately modifying the inflammatory ...

3 天之前 · Single-cell transcriptome aging clocks predict biological age. We developed immune cell-type-specific transcriptome aging clocks, sc-ImmuAging, for human PBMCs (Fig. 1), using scRNA-seq datasets ...