2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。 * Please select Quantity before adding items. • Nature. 2025 Jan 15. [Abstract] • Signal Transduct Target Ther. 2023 Feb 15;8 (1):65. [Abstract] • Cell Res. 2021 Mar;31 (3):291-311. [Abstract] • Cancer …

2-Deoxy-d-glucose is a glucose molecule which has the 2- hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis).

2-deoxy-D-glucose (2DG) is a fake sugar that cancer cells eagerly absorb, preventing them from taking in real sugar and growing. This accumulation of 2DG slows down cancer cells, making them weaker and more vulnerable to treatments.

2-DG (2-Deoxy-D-glucose), 一种葡萄糖类似物，是具有抗病毒活性的 糖酵解 抑制剂。 2-Deoxy-D-glucose 可诱导凋亡并抑制 Herpes Simplex Virus type-1 (HSV-1) receptor 的表达。 2-Deoxy-D-glucose和Albendazole联合使用对治疗人包虫病显示出高效。 Xin Q, et al. PLoS Negl Trop Dis. 2022 Jul 18;16 (7):e0010618. 2-Deoxy-D-glucose和Fenofibrate在不同的肿瘤细胞系中诱导坏死和凋亡细胞死亡。 Liu H, et al. Oncotarget. 2016 Jun 14;7 (24):36461-36473.

2-Deoxy-D-glucose (2-DG, 2-deoxy-D-arabino-hexopyranose) is a natural [1], nonmetabolizable glucose analog and a competitive inhibitor of glycolysis [2] in which the 2-hydroxyl group is replaced by hydrogen (Figure 1). 2-DG blocks the activity of different enzymes involved in glycolysis, leading to cell death.

By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism, which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease. Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent.

2021年12月6日 · Here, we show that both compounds selected wild-type over mutant mtDNA, restoring mtDNA expression and respiration. Mechanistically, 2DG selectively inhibits the replication of mutant mtDNA; and...

2-Deoxy-D-glucose (2-脱氧-d-葡萄糖)是一种葡萄糖抗代谢物和 糖酵解抑制剂，它抑制己糖激酶（将葡萄糖转化为葡萄糖 6-磷酸的酶）和 磷酸葡萄糖异构酶 （将葡萄糖转化为 6-磷酸的酶）。 2-脱氧-D-葡萄糖 (16 mM) 在SK-BR-3细胞中诱导细胞凋亡，并在使用浓度为2时抑制在缺氧条件下培养的骨肉瘤细胞的生长。 储藏条件 ：储存温度2-8℃。 2-Deoxy-D-glucose (2-脱氧-d-葡萄糖)是一种葡萄糖抗代谢物和糖酵解抑制剂，它抑制己糖激酶（将葡萄糖转化为葡萄糖 6-磷酸的酶）和 …

2024年3月13日 · 2-脱氧-D-葡萄糖（2-DG）是一种葡萄糖类似物，在生物医学研究中具有独特价值。 它可应用于细胞代谢、肿瘤生物学、神经科学和心血管疾病等领域。 尽管其应用前景广阔，但仍需深入研究其作用机制和安全性。 在生物医学研究的广阔领域中，糖类化合物一直扮演着至关重要的角色。 它们不仅是生物体能量供应的主要来源，还参与细胞信号传导、蛋白质糖基化等关键生物过程。 近年来，一种名为2-脱氧-D-葡萄糖（2-Deoxy-D-glucose，简称2-DG）的糖类化合 …

The ability of 2-deoxy- d -glucose (2-DG) to interfere with d -glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival.