Chondroblasts (AKA perichondrial cells) are cells that play an important role in the formation of cartilage (AKA chondrogenesis). They are located in the perichondrium, which is a layer of connective tissue that surrounds developing bone and also helps protect cartilage.

Chondroblasts, or perichondrial cells, is the name given to mesenchymal progenitor cells in situ which, from endochondral ossification, will form chondrocytes in the growing cartilage matrix. Another name for them is subchondral cortico-spongious progenitors. [1] They have euchromatic nuclei and stain by basic dyes.

Chondroblasts are pivotal players in maintaining healthy cartilaginous structures throughout life—from embryonic development through adulthood—by producing essential components necessary for proper function within joints.

Describe the relationship between chondroblasts and chondrocytes in the context of cartilage formation and maintenance. Chondroblasts are the precursor cells responsible for the formation and growth of cartilage, while chondrocytes are the mature cartilage cells that maintain and repair the cartilage matrix.

Chondroblasts are a type of immature cells whereas chondrocytes are a type of mature cells. The main difference between chondrocytes and chondroblasts is that chondroblasts secrete the extracellular matrix of the cartilage whereas chondrocytes are involved in the maintenance of the cartilage.