Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway.

This review summarizes the most recent research on drug development against mTOR, 4E-BP1, and eIF4E, describing the design rationale and the available structural and functional data on the most promising compounds.

After treatment of cells with serum, growth factors, or hormones, 4E-BP1 (the prototype member of the family), is hyperphosphorylated in a wortmannin- and rapamycin-sensitive manner, and dissociates from eIF4E (Beretta et al. 1996; von Manteuffel et al. 1996, 1997).

Decline of protein quality control in neurons contributes to age-related neurodegenerative disorders caused by misfolded proteins. 4E-BP1 is a key node in the regulation of protein synthesis, as activated 4E-BP1 represses global protein translation.

2021年6月3日 · To resolve the mechanism of this hierarchical phosphorylation at the atomic level, we monitored by NMR spectroscopy the interaction of intrinsically disordered 4E binding protein isoform 1 (4E-BP1) with the mTORC1 subunit regulatory-associated protein of mTOR (Raptor).

2025年3月28日 · EIF4EBP1 (Eukaryotic Translation Initiation Factor 4E Binding Protein 1) is a Protein Coding gene. Diseases associated with EIF4EBP1 include Tuberous Sclerosis and Rhabdomyosarcoma. Among its related pathways are Translation Insulin regulation of translation and Peptide chain elongation.

2016年2月1日 · Here we describe the molecular and cellular functions of 4E-BP1 and highlight the distinct roles of 4E-BP1 in cancer depending on the microenvironmental context of the tumor.

1999年6月1日 · Binding of the 4E-BPs to eIF4E is regulated by phosphorylation: Hypophosphorylated 4E-BP isoforms interact strongly with eIF4E, whereas hyperphosphorylated isoforms do not. 4E-BP1 is hypophosphorylated in quiescent cells, but is hyperphosphorylated on multiple sites following exposure to a variety of extracellular stimuli.

Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) is a member of a family of translation repressor proteins, and a well-known substrate of mechanistic target of rapamycin (mTOR) signaling pathway.

2012年6月29日 · A nonphosphorylatable 4E-BP1 mutant was found to be ubiquitinylated more extensively than wild-type (WT) 4E-BP1, suggesting that increased ubiquitinylation of 4E-BP1 (α) is a key to its disappearance from eIF4E-KD cells.