2021年2月24日 · Here we present crystal structures of SARS-CoV-2 NSP13 solved in the APO form and in the presence of both phosphate and a non-hydrolysable ATP analog. Comparisons of these structures reveal details of conformational changes that provide insights into the helicase mechanism and possible modes of inhibition.

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Biological Unit for 7NNG: monomeric; determined by author and by software (PISA)

Helicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a critical role catalysing the …

2021年8月11日 · Structural analysis reveals two “druggable” pockets on NSP13 that are among the most conserved sites in the entire SARS-CoV-2 proteome. Here we present crystal structures of SARS-CoV-2 NSP13 solved...

2021年2月24日 · Title: Crystal structure of the SARS-CoV-2 helicase in complex with Z2327226104. PDB DOI: https://doi.org/10.2210/pdb7nng/pdb. Primary publication DOI: …

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7nng is a 2 chain structure with sequence from 2019-ncov. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. [ …

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