AG-1478 (Tyrphostin AG-1478) | EGFR Inhibitor | MedChemExpress
2016年10月3日 · AG1478 (2 μM) suppresses the phosphorylation of EGFR and ERK1/2 and subsequently upregulates the expression of ZO-1 and occludin in BEAS-2B cells. AG-1478 …
AG-1478 | 99.92% (HPLC) | In Stock | EGFR inhibitor
AG-1478 is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits …
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The Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase …
We now show that AG1478 increases binding of mAb 806 to the cell surface through two distinct mechanisms: an immediate effect on the conformation of EGFR and a longer term increase in …
Tyrphostin AG 1478 - Cell Signaling Technology
2025年4月2日 · Tyrphostin AG 1478 is a tyrosine kinase inhibitor specifically selective to EGFR (ErbB1), with an IC 50 of about 3 nM in vitro (1,2). Treatment of cell with 50-150 nM of AG …
AG1478 Elicits a Novel Anti-Influenza Function via an EGFR
2022年5月16日 · In the present study, we serendipitously found that a small-molecule inhibitor (AG1478), previously used for epidermal growth factor receptor (EGFR) inhibition, …
The epidermal growth factor tyrosine kinase inhibitor AG1478 …
Our data show that both AG1478 and erlotinib potently sensitized drug-resistant cells overexpressing either wild type or mutated ABCG2 to the ABCG2 substrate anticancer drugs …
AG 1478 hydrochloride | EGFR | Tocris Bioscience
AG 1478 hydrochloride is a potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits …
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AG1478 Elicits a Novel Anti-Influenza Function via an EGFR …
In the present study, we serendipitously found that a small-molecule inhibitor (AG1478), previously used for epidermal growth factor receptor (EGFR) inhibition, demonstrated a potent …
AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride)
AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and …
AG 1478 - Laboratory Notes
AG1478, a selective tyrosine kinase inhibitor, demonstrates high specificity for the epidermal growth factor receptor (EGFR), a transmembrane protein crucial for regulating cellular …