2024年12月24日 · ARG2 (Arginase 2) is a Protein Coding gene. Diseases associated with ARG2 include Urea Cycle Disorder and Argininemia . Among its related pathways are superpathway of L-citrulline metabolism and Metabolism of proteins .

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II, this enzyme) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.

2021年3月5日 · Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for...

2025年1月4日 · Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function.

2019年4月8日 · Here we identify arginase 2 (Arg2) as a fasting-induced hepatocyte factor that protects against hepatic and peripheral fat accumulation, hepatic inflammatory responses, and insulin and glucose...

In this study, we found that ARG2 deficiency inhibited senescence and apoptosis of NPCs, and degeneration of the ECM induced by oxidative stress and the inflammatory response. Similar results were found with the selective NF-κB pathway inhibitor JSH-23. In contrast, overexpression of ARG2 had the opposite effect.

At least two isoforms of mammalian Arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney.

肝细胞arg2负责全身产热、胰岛素和葡萄糖耐受. arg2促进尿素循环功能，而尿素循环受损会通过tca循环中nadh生成不足引发线粒体功能障碍。因此，作者测试了尿素循环受损是肝脂肪变性及胰岛素抵抗发病机制中诱发事件的假设。

Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration.

急性肾衰竭、终末期肾病、高血压和输尿管梗阻的生物标志物。 该基因的人类同源物与哮喘有关。 与人类的ARG2 (精氨酸酶2)正交。 [由基因组资源联盟，2022年4月提供] Dir./Indir. A tissue-specific atlas of mouse protein phosphorylation and expression. Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.