2024年12月24日 · ATG3 (Autophagy Related 3) is a Protein Coding gene. Diseases associated with ATG3 include Neurodegeneration With Brain Iron Accumulation and Granulomatous Amebic Encephalitis. Among its related pathways are Autophagy and Selective autophagy.

2021年6月21日 · Here, we summarize the current knowledge of ATG3 in autophagosome formation, highlight its binding partners and binding sites, review its autophagy-dependent functions, and provide a brief introduction into its autophagy-independent functions.

ATG3 is one of the key genes involved in autophagy, and its homologs are common in eukaryotes. During autophagy, ATG3 acts as an E2 ubiquitin-like conjugating enzyme in the ATG8 conjugation system, contributing to phagophore elongation.

Dysfunctional autophagy by Atg3 deletion inhibited mitochondrial removal during pluripotency induction, resulting in decreased reprogramming efficiency and accumulation of abnormal mitochondria in established iPSCs.

2023年9月7日 · Atg3, an E2-like enzyme, catalyzes the transfer of LC3 from LC3-Atg3 to PEs in targeted membranes. Here we show that the catalytically important C-terminal regions of human Atg3 (hAtg3) are conformationally dynamic and directly interact with the membrane, in collaboration with its N-terminal membrane curvature-sensitive helix.

2018年1月8日 · Here we report a thiol-dependent process that may account for impaired autophagy during aging. This is through direct oxidation of key autophagy-related (Atg) proteins Atg3 and Atg7. When...

2020年5月26日 · Atg3/ATG3 acts as the E2-like enzyme that catalyzes lipidation of Atg8/LC3 family proteins by localizing to the PAS and the phagophore (Fig. 6a) 152,153,154,155.

2016年10月20日 · Tsuboyama et al. identified an unexpected role of ATG3, an important enzyme in the ATG conjugation systems, in efficient degradation and opening of the inner autophagosomal membrane after fusion with lysosomes (see the Perspective by Levine). Their live-imaging system revealed the entire life of an autophagosome in mammalian cells.

2023年9月7日 · Atg3, an E2-like enzyme, catalyzes the transfer of LC3 from LC3-Atg3 to PEs in targeted membranes. Here we show that the catalytically important C-terminal regions of human Atg3 (hAtg3) are...

2023年6月23日 · From these findings, we propose that AH ATG3 plays a central role in ATG3 enzymatic reaction by organizing the overall structure of the ATG3~LC3 conjugate on membranes, and the unique properties of the AH ensure a transient membrane association of …