2 天之前 · ATP11B is a P4-ATPase and the expression of Atp11b changes in the brain of patients with AD and diseases of lipid metabolism. The present study aimed to explore the regulatory role of ATP11B in microglial lipid metabolism and assess the …

2024年12月24日 · ATP11B (ATPase Phospholipid Transporting 11B (Putative)) is a Protein Coding gene. Diseases associated with ATP11B include Hypoparathyroidism, X-Linked and Currarino Syndrome. Among its related pathways are …

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+).

1、评估磷脂翻转酶ATP11B在多种脑细胞中的表达. 2、构建Atp11b KO大鼠，系统敲除大鼠的Atp11b基因. 3、评估Atp11b KO大鼠的内皮细胞是否存在功能障碍. 4、通过MRI观察Atp11b KO大鼠脑部的影像学变化. 5、通过多项行为学测试分析Atp11b KO大鼠的行为特征变化. 四、研究结果

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu (2+) or Cd (2+).

2025年2月8日 · P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu (2+) or Cd (2+).

We show that ATP11B/ATP11B is heterogeneously expressed in ECs in normal rat and human brain even in the same transverse section of the same blood vessel, suggesting variable effects of the loss of ATP11B on each vessel and an explanation for the patchy nature of the disease.

P-型ATP酶，如ATP11B，在它们的中间状态被磷酸化，并驱动离子在膜上的向上运输。 已经识别出P-型ATP酶的几个亚家族。 一个亚家族运输重金属离子，如Cu (2+)或Cd (2+)。 另一个亚家族运输非重金属离子，如H (+)，Na (+)，K (+)，或Ca (+)。 第三个亚家族运输两亲物，如磷脂酰丝氨酸。 [由OMIM于2005年2月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 Lineage-specific biology revealed by a finished genome assembly of the mouse. P-型ATP酶，如ATP11B，在它 …

2019年8月19日 · In the present study, abnormal neural and dendritic morphology was observed in the hippocampus following knockout of Atp11b both in vitro and in vivo. Moreover, ATP11B modified synaptic ultrastructure and promoted spine remodeling via the asymmetrical distribution of phosphatidylserine and enhancement of glutamate release, glutamate receptor ...

与人ATP11B（ATP酶磷脂转运体11B（推测））正同源。 [由基因组资源联盟，2022年4月提供] 当前研究发现，Atp11b基因存在5种不同的转录本和5种不同的蛋白质变体。 该基因暂未发现相关的转录本和蛋白质序列信息。 Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control. Lineage-specific biology revealed by a finished genome assembly of the mouse.