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Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in …
2023年1月15日 · The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-binding cassette (ABC) efflux transporter. It was so named because it was initially cloned from a multidrug-resistant breast cancer cell line where it was found to confer ...
Banco Central de Reserva del Perú
Acreditación de poderes ante el BCRP El Museo Central (MUCEN) es la red de museos del Banco Central de Reserva del Perú, un espacio cultural en el que el diálogo es usado como herramienta para generar comunidad.
BCRP - Transporters - Solvo Biotechnology
ABCG2, more commonly referred to as BCRP (Breast Cancer Resistance Protein), is an efflux transporter that serves two major drug transport functions. Firstly, it restricts the distribution of its substrates into organs such as the brain, testes, placenta, and …
Home - BCRP
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Targeting breast cancer resistance protein (BCRP/ABCG2) in cancer
How to design a novel, effective and non-toxic BCRP inhibitor to reverse the MDR of breast cancer, and boost the success rate of chemotherapy is a serious challenge at present. A detailed overview of the molecular role of BCRP-mediated breast cancer MDR and its inhibitors reported in recent years is provided in this article.
Novel inhibitors of breast cancer resistance protein (BCRP, ABCG2 ...
2023年2月1日 · Breast cancer resistance protein (BCRP) is a clinically relevant ATP-binding cassette (ABC) transporter for drug disposition. Inhibition of BCRP increases the plasma concentrations of BCRP substrate drugs, which potentially could lead to adverse drug reactions.
ABC Transporters: The Breast Cancer Resistance Protein
2022年1月1日 · BCRP is a membrane-bound transporter that can bind substrate molecules and transfer them across that lipid bilayer. When positioned at a cell’s external membrane, BCRP transport is directed toward the extracellular fluid, which decreases the amount of BCRP substrates within that cell.
Breast Cancer Resistance Protein: A Potential Therapeutic
Breast Cancer Resistance Protein (BCRP) is an efflux transporter responsible for causing multidrug resistance (MDR). It is known to expel many potent antineoplastic drugs, owing to its efflux function.
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