2020年2月12日 · Objective To compare established associations between risk factors and mortality in UK Biobank, a study with an exceptionally low rate of response to its baseline survey, against those from representative studies that have conventional response rates. Design Prospective cohort study alongside individual participant meta-analysis of other cohort studies. …

Introduction Chronic depression represents a common and highly disabling disorder. Several randomised controlled trials (RCTs) investigated the effectiveness of psychological, pharmacological and combined treatments for chronic depression. This is the first overarching systematic review and network meta-analysis (NMA) based on aggregated and individual …

High impact medical journal. Champion of better research, clinical practice & healthcare policy since 1840. For GPs, hospital doctors, educators, policymakers.

2025年1月31日 · By David Albert Jones ‘When I use a word,’ Humpty Dumpty said in rather a scornful tone, ‘it means just what I choose it to mean — neither more nor less.’ ‘The question is,’ said Alice, ‘whether you can make words mean so many different things.’

We and our 138 partners store and access personal data, like browsing data or unique identifiers, on your device. Selecting "I Accept" enables tracking technologies to support the purposes shown under "we and our partners process data to provide," whereas selecting "Reject All" or withdrawing your consent will disable them.

Objective To describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIMs) and their major subgroups. Methods An international, multidisciplinary group of myositis experts produced a set of 93 potentially relevant variables to be tested for inclusion in the criteria. Rheumatology, dermatology, neurology and …

Results The number of assisted deaths in Oregon increased from 16 in 1998 to 278 in 2022. Over this time, patients’ health funding status changed from predominantly private (65%) to predominantly government support (79.5%), and there was an increase in patients feeling a burden and describing financial concerns as reasons for choosing an assisted death.

2025年1月31日 · Researchers need to do more to ensure that their study participants are diverse and representative of the patient population, while medical journals should reject papers that do not meet those criteria, health and charity leaders have said. John James, chief executive officer of the Sickle Cell Society, urged medical journal editors to be tougher when it comes to not …

Objectives To determine patient-reported symptoms and clinical factors associated with mimics and differences in health-seeking behaviour versus stroke. Design This is a post-hoc analysis of a cross-sectional survey of interviews on patient-reported factors in patients admitted with suspected stroke. Patients were categorised as genuine stroke or mimic. The surveys were …

2025年3月6日 · Robust legal, medical, and ethical oversight of assisted dying is essential, writes Richard Huxtable Assisted dying for terminally ill people is set to soon become lawful in the Isle of Man.1 It is on the legal horizon in England and Wales too, as the Terminally Ill Adults (End of Life) Bill is currently proceeding through parliament.2 Introducing its second reading in November …