The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (C luster of D ifferentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor. [5] .

补体过敏毒素 C5a 是宿主防御的促炎成分，通过两种已识别的受体 C5a 受体 (C5aR) 和 C5L2 发挥作用。C5aR 是经典的 G 蛋白偶联受体，而 C5L2 结构同源但缺乏 G 蛋白偶联。在人类中性粒细胞中，我们发现 C5L2 主要在细胞内表达，而 C5aR 在质膜上表达。

2024年12月24日 · C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Atypical Hemolytic-Uremic Syndrome and Hypersensitivity Reaction Type Iii Disease. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Complement cascade.

2018年2月13日 · Complement component fragment 5a receptor (C5aR) is one among the two chemoattractant receptors known in the rhodopsin family of G-protein coupled receptors (GPCR) 1....

2023年2月17日 · Here, we present cryo-electron microscopy structures of the activated wild-type C5aR1–G i protein complex bound to each of the following: C5a, the hexapeptidic agonist C5a pep, and the G...

2018年6月4日 · Targeting C5aR has emerged as a novel anti-inflammatory therapeutic method. However, developing potent C5aR antagonists as drugs has proven difficult. Here, we report two crystal structures of...

2019年6月15日 · Complement activation generates the core effector protein C5a, a potent immune molecule that is linked to multiple inflammatory diseases. Two C5a receptors, C5aR1 (C5aR, CD88) and C5aR2 (C5L2, GPR77), mediate the biological activities of C5a. Although C5aR1 has broadly acknowledged proinflammatory r …

C5a anaphylatoxin receptor (C5aR) is a G protein-coupled receptor for C5a and modulates inflammatory responses, obesity, development and cancers.

2016年2月16日 · The anaphylatoxin receptor C5aR is one of the two major G-protein coupled receptors (GPCRs) identified in the human genome that interact with the complement component fragment 5a (hC5a), the most potent proinflammatory polypeptide of the complement system.

The complement anaphylatoxin C5a is a proinflammatory component of host defense that functions through two identified receptors, C5a receptor (C5aR) and C5L2. C5aR is a classical G protein-coupled receptor, whereas C5L2 is structurally homologous but deficient in …