1990年7月6日 · The cellular localization, functional activities and structures of rat and human Clara cell 10 kDa proteins (CC10) are compared to rabbit uteroglobin. CC10 is present exclusively in the non-ciliated cells of the surface epithelium of the pulmonary airways, whereas uteroglobin is reported to be prese …

Club cell 10-kDa protein (CC10) is a documented biomarker for airway obstructive diseases. Primarily produced by nonciliated club cells in the distal airway and in nasal epithelial cells, CC10 suppresses Th2 cell differentiation and Th2 cytokine production.

1997年3月18日 · The CC10 deficient mice demonstrate an increased susceptibility to hyperoxic injury and an exaggerated inflammatory response . Despite extensive characterization of the structure of CC10, there is only indirect evidence of its physiologic role in the lung.

Individuals who are over age 65 and individuals with serious underlying health conditions, such as high blood pressure, chronic lung disease, diabetes, obesity, asthma, and those whose …

Recombinant human CC10 protein (rhCC10) is a novel therapeutic agent developed for the prevention or treatment of respiratory diseases associated with marked inflammation. rhCC10 administration has been shown to significantly improve lung structure and function in animal models of lung injury by: 1) reducing lung inflammation; 2) upregulating ...

We have shown that a large fragment (-2339 to +57) from the rat CC10 gene directed lung-specific expression of a reporter construct in transgenic animals.

Human Club Cell Protein (CC16, CC10 and also called uteroglobin, urinary protein 1 or Clara Cell Secretory Protein) belongs to the family of secretoglobins and is a secreted protein product of non-ciliated bronchiolar Club cells.

Like ILC2s, Clara cell 10-kD protein (CC10) has the potential to regulate AR. It belongs to the secretoglobin family. Found only in mammals, CC10 acts as an anti-inflammatory and immunomodulatory effector [16–19].

Clara cell 10-kD protein (CC10) possesses antiinflammatory and immunomodulatory effects. Down-regulated expression of CC10 is associated with inflammatory upper airway diseases, but a causal role for CC10 in upper airway diseases has not been determined.