CD2 is a transmembrane molecule belonging to the immunoglobulin supergene family that plays a crucial role in T-cell activation, cytolysis, apoptosis, and cytokine production. It is expressed by thymic T-cells, peripheral T-cells, NK cells, and a subset of …

2024年12月24日 · Complete information for CD2 gene (Protein Coding), CD2 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium.

2020年6月8日 · CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and antigen-presenting cells upon cell-cell conjugation and associated intracellular signaling.

2022年8月5日 · CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in mice and CD58 in humans, that are present on antigen-presenting cells (APCs). However, both CD48 and CD58 are also expressed on T cells.

The CD2 molecule is a 50-55KD transmembrane glycoprotein expressed on the vast majority of thymocytes and virtually all peripheral T lymphocytes. Its functions are two-fold: adhesion and activation.

2020年6月9日 · Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation.

CD2 serves as a paradigm for the multitude of adhesion-receptors now being described and characterized. Detailed understanding of each molecule will allow synthesis of an integrated understanding of cellular and molecular interaction during immunity.

2020年9月14日 · Human CD2 (hCD2) and its ligand CD58 were identified by monoclonal antibodies that inhibit T cell killing of alloreactive target cells 1. All mature human T cells express CD2, with higher...

1997年2月15日 · The CD2 glycoprotein has been implicated in both positive and negative regulation of T-cell mitogenesis. To study the involvement of CD2 in T-lymphocyte development and immune responses, we have analyzed two lines of CD2-null mice, each expressing a distinct class I major histocompatibility complex (MHC)-restricted T-cell receptor (TCR).

2024年6月5日 · Cluster of Differentiation 2 (CD2) is a glycoprotein expressed on the surface of T cells and natural killer (NK) cells, playing a pivotal role in cellular adhesion and immune responses. In this blog post, we delve into the significance of CD2, its functions, and its impact on the immune system.