CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels.

This review summarizes recent data on CD23, a low affinity receptor for IgE (Fc epsilon RII). CD23 is the only FcR which does not belong to the immunoglobulin gene superfamily. The CD23 molecule was discovered independently as an IgE receptor on human lymphoblastoid B cells [1], as a cell surface ma …

2024年3月21日 · cd23是一种低亲和力ige受体，是一种c型凝集素，在调节ige产生，b细胞分化，免疫细胞激活以及过敏反应调节中扮演着重要角色，是过敏疾病治疗的潜在靶点。

2016年5月16日 · To understand the molecular mechanism by which CD23 negatively regulates BCR-mediated B-cell activation, we examined the relative expression levels of CD23 in peripheral B cells and the effects...

CD23/FcεRII, the low-affinity receptor for IgE, is constitutively expressed on B cells and has been shown to regulate immune responses. Simultaneous binding of IgE to FcεRI and CD23 is blocked by reciprocal allosteric inhibition, suggesting that the …

2020年12月30日 · While evidence from experimental disease models as well as allergic patient studies on CD23 is still lacking, evidence shows that i) CD23 can absorb and clear IgE from the serum in a non-inflammatory fashion, ii) CD23 reduces the synthesis of IgE from B cells, iii) CD23 regulates antigen-specific IgG and T cell responses.

2024年8月21日 · CD23是一种种低亲和力IgE受体，在调节IgE产生和B细胞分化中具有重要作用。 在B细胞上中，启动IgE依赖性抗原摄取并呈递给T细胞。 在巨噬细胞中， IgE 结合和抗原交联通过激活L-精氨酸-一氧化氮途径触发细胞内杀死寄生…

The association of immunoglobulin E (IgE) with allergic diseases and asthma is well established. IgE binds to two receptors on various immune and inflammatory cells. The lower-affinity IgE Fc receptor, CD23, has multiple functions in enhancing the ...

CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities.

39.5.2.2 CD23 (FcεRII): The Low-affinity Receptor for IgE. CD23 is a type II integral membrane protein with an extracellular C-terminal domain that is homologous to C-type lectins.