CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1]

CD3 is an essential T cell co-receptorand defines T cell lineage. CD3is therefore an ideal T cell marker. This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

Anti-CD3 antibodies act as potent immunosuppressive agents by modulating the CD3/T-cell receptor (TCR) complex. They have been used in patients to prevent short term allograft rejection and were also shown to induce long-term remission of autoimmune diabetes in nonobese diabetic (NOD) mice [8].

2025年1月15日 · Explore the roles of CD3, CD4, and CD8 in T-cell dynamics and their impact on immune response and signaling. T-cells are a key component of the adaptive immune system, playing a role in identifying and eliminating pathogens.

2022年3月18日 · CD3 is first expressed in the cytoplasm of developing T cells, then as they mature it moves to the membrane (Immunity 2006;24:133) Activation of the TCR by antigen peptides, presented via major histocompatibility complexes, induces phosphorylation of intracellular immunoreceptor tyrosine based activation motifs (ITAMs) in the CD3ζ subunits ...

2 天之前 · CD3-directed agents vary in therapeutic applications, safety profiles, and mechanisms of action. Differences in antibody affinity, isotype selection, and molecular modifications influence T-cell activation and immune modulation. Some agents induce potent T-cell activation for cytotoxic responses, while others promote immune tolerance or ...

2007年7月20日 · CD3-specific monoclonal antibodies inactivate pathogenic cells by inducing rapid internalization of the T-cell receptor (TCR)–CD3 complex from the cell surface.

CD3 complex provides the first signal sensed by the TCR of the lymphocyte to trigger its activation. Thus, it becomes a very attractive receptor to determine the fate of the immune response in different contexts from tolerance induction to immune activation.

2024年6月7日 · CD3 is a pivotal component of the immune system, playing a crucial role in the activation and function of T cells. Its importance in immune signaling and regulation makes it a key target for therapeutic interventions and a valuable marker in clinical diagnostics.

CD3 Complex / immunology Humans Lymphoma, T-Cell / diagnosis* Receptors, Antigen, T-Cell / immunology Staining and Labeling T-Lymphocytes / immunology Substances Antibodies, Monoclonal Biomarkers, Tumor ...