CD99 acts through homophilic interactions and enables homo- or heterotypic cell aggregation. CD99 can mediate diverse cellular processes such as adhesion, transendothelial migration, differentiation, and cell death, thereby affecting immune …

2024年12月24日 · CD99 (CD99 Molecule (Xg Blood Group)) is a Protein Coding gene. Diseases associated with CD99 include Extraosseous Ewing Sarcoma and Lymphoblastic Lymphoma . Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation .

This review summarizes the recent progress of CD99 in cancer research and targeting therapies, especially in cancer immunotherapy, which may help researchers understand the crucial roles of CD99 in cancer development and design new therapeutic strategies.

CD99 is a cell surface protein with unique features and only partly defined mechanisms of action. This molecule is involved in crucial biological processes, including cell adhesion, migration, death, differentiation and diapedesis, and it influences processes associated with …

CD99 is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, and transmembrane protein transport, and also in T-cell death by a caspase-independent pathway. It may have the ability to rearrange the actin cytoskeleton, and may also act as an oncosuppressor in osteosarcoma.

2018年2月5日 · CD99 (MIC2) is a widely expressed cell surface glycoprotein and functions as a tumor suppressor involved in downregulation of SRC family of tyrosine kinase. CD99 expression is tightly regulated...

2002年1月14日 · CD99 is a heavily O-glycosylated 32-kD type I transmembrane protein that is expressed on most hematopoietic cells. We show here that CD99 is expressed on endothelial cells and is...

2018年1月25日 · CD99, a glycosylated transmembrane protein, is involved in many essential cellular functions. For example, cell adhesion and migration, cell death and differentiation, intracellular protein trafficking, endocytosis and exocytosis are influenced by the CD99-regulated signaling. Figure 1 schematizes the effects of CD99 on biological processes.

2022年5月28日 · In this study, we aimed to understand the role of CD99 in the skin using normal human epidermal keratinocytes (NHEK). CD99 expression increased with the confluency of NHEK, while the CD99-high expressing NHEK lost their stem cell properties and played a role in barrier function.

In order to analyze the relevance of CD99 for diapedesis of myeloid cells in vivo, we used a blocking monoclonal antibody against the homologue mouse CD99. Our results demonstrate in a peritonitis model, that CD99 is necessary for extravasation of both monocytes and neutrophils.