Cullin 3 is a protein that in humans is encoded by the CUL3 gene. [5] [6] [7] Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, Cullin 5, Cullin 7 and Cullin 9). [8]

2024年12月24日 · CUL3 (Cullin 3) is a Protein Coding gene. Diseases associated with CUL3 include Pseudohypoaldosteronism, Type Iie and Neurodevelopmental Disorder With Or Without Autism Or Seizures. Among its related pathways are Class I MHC mediated antigen processing and presentation and MAPK family signaling cascades.

2023年9月12日 · CUL3-related neurodevelopmental disorder is a condition that affects neurological and physical development. Children with CUL3 -related neurodevelopmental disorder may have intellectual disability or specific learning disorders.

CUL3-related syndrome is also called CUL3-related neurodevelopmental disorder. For this webpage, we will be using the name CUL3-related syndrome to encompass the wide range of variants observed in the people identified.

The CUL3 gene provides instructions for making a protein called cullin-3. This protein plays a role in the ubiquitin-proteasome system, which breaks down (degrades) unwanted proteins inside cells.

A non-profit patient advocacy group to help foster connection, provide support, increase awareness, and advance research for CUL3-related neurodevelopmental disorder.

What is CUL3-related Neurodevelopmental Disorder? CUL3 is not the name of a disease or disorder, but rather it is the name of a gene located on the 2nd chromosome. The CUL3 gene provides instructions that tell the body how to make a protein called Cullin3.

The most commonly asked questions about CUL3-related neurodevelopmental disorder.

2025年2月9日 · Title: Prognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumors. circCUL3 drives malignant progression of cervical cancer by activating autophagy through sponge miR-223-3p upregulation of ATG7.

2021年5月24日 · De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). In mouse, constitutive Cul3 haploinsufficiency leads to...