2024年12月24日 · CUX1 (Cut Like Homeobox 1) is a Protein Coding gene. Diseases associated with CUX1 include Global Developmental Delay With Or Without Impaired Intellectual Development and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are FGFR1 mutant receptor activation and Vesicle-mediated transport.

CUX1 is an animal gene. The name stands for Cut like homeobox 1. The term "cut" derives from the "cut wing" phenotype observed in a mutant of Drosophila melanogaster. [1] In mammals, a CCAAT-displacement activity was originally described in DNA binding assays. [2]

2016年12月2日 · CUX1 is located at chromosome 7q22.1; -7/del(7q) involving CUX1 locus are common abnormalities in myelodysplastic syndromes (MDS). Mutations and loss of heterozygosity involving CUX 1 have been also described in breast, lung and uterine cancers.

2023年8月30日 · We analyze brain CUX1 expression and susceptibility to epilepsy in Cux1+/− mice. We describe 34 individuals, from which 30 were unrelated, with 26 different null and four missense variants.

2021年4月30日 · Cut-like homeobox 1 (CUX1) is a haploinsufficient tumor suppressor commonly inactivated in acute myeloid leukemia and high-risk myelodysplasia.

By alternative transcriptional initiation and/or proteolytic processing, CUX1 generates several short isoforms that possess distinct DNA-binding capacity and transcriptional activities compared to the full-length CUX1 (p200 CUX1). p200 CUX1 binds to DNA in a rapid but transient manner and exclusively functions as a transcriptional repressor ...

2014年9月5日 · Nature Reviews Cancer - CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour suppression and progression. What are the functions of the CUX1 protein, and how might...

2024年5月12日 · CUX1 is a homeodomain-containing transcription factor that is essential for the development and differentiation of multiple tissues. CUX1 is recurrently mutated or deleted in cancer, particularly in myeloid malignancies. However, the mechanism by which CUX1 regulates gene expression and differentiation remains poorly understood, creating a ...

Cux1 is a tumor suppressor and inactivating CUX1 mutations promote tumorigenesis. Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD.

数据库分析结直肠癌患者的癌组织和癌旁组织中cux1的表达情况,通过实时荧光定量pcr(qrtGpcr)检测 cux1在结直肠癌组织中的表达情况;利用gepia数据库分析cux1表达对结直肠癌患者术后总体生存率的影