CD34 is primarily known as a biomarker for hematopoietic stem cells (HSCs) and hematopoietic stem precursor cells, but it has also been identified as a marker for several non-hematopoietic cells.

CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to these historical ...

2024年12月24日 · CD34 (CD34 Molecule) is a Protein Coding gene. Diseases associated with CD34 include Dermatofibrosarcoma Protuberans and Cutaneous Fibrous Histiocytoma. Among its related pathways are Innate Immune System and Class I …

2017年12月26日 · For almost 30 years, the cell-surface sialomucin CD34 has been used as a marker to identify and enrich HSPCs in preparation for BM transplantation. 1 However, studies have revealed that the CD34 neg fraction of normal human BM is capable of differentiating into CD34 pos subsets that possess a more activated phenotype. 4-6,15 However, the CD34 ...

CD34 is a marker of human HSC, and all colony-forming activity of human bone marrow (BM) cells is found in the CD34+ fraction. Clinical transplantation studies that used enriched CD34+ BM cells indicated the presence of HSC with long-term BM reconstitutional ability within this fraction.

CD34 is a transmembrane glycoprotein that is expressed on early lymphohematopoietic stem cells, progenitor cells, endothelial cells, embryonic fibroblasts, and some cells in fetal and adult nervous tissue. It is also expressed on pluripotent and committed stem cells in …

2023年8月19日 · The sialomucin, CD34, is widely used as an endothelial marker. However, CD34 is differentially expressed on endothelial cells in different organs and in pathological conditions.

2023年7月14日 · This review recaptures CD34 structure, evolutionary conservation, proposed functions, and role in lung inflammation, to describe current research findings and to provide guidance for future studies on CD34.

CD34 is a type I transmembrane glycophosphoprotein that has been used as the hallmark for clinical identification and enrichment of hematopoietic stem cells for several years (Sato et al., 1999).

2023年5月12日 · CD34 is commonly used as a marker to identify and isolate CSCs in various types of cancer. CD34-positive CSCs have been identified in leukemia, breast cancer, lung cancer, and other types of tumors. These CD34-positive CSCs have been shown to have enhanced self-renewal ability and increased tumor-initiating capacity compared to CD34 …