2025年3月28日 · CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and …

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

大鼠 Rat Cd40lg 靶点分子功能（预测） Enables CD40 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of MHC class II biosynthetic process; and positive regulation of cytokine production.

CD40 配体 (CD40LG/CD154/TNFSF5)是CD40的天然三聚体配体，是一种39kDa的II型膜糖蛋白，其在多种细胞类型上表达，包括活化的CD4+T细胞、活化的B细胞、记忆CD8+T细胞、激活的自然杀伤细胞、粒细胞、内皮细胞、平滑肌细胞、巨噬细胞和活化血小板。 CD40是在各种免疫细胞（如B细胞、树突细胞和巨噬细胞）上表达的受体蛋白。 CD40L可与CD40相互作用，触发这些免疫细胞的过度刺激，导致免疫反应级联和介导炎症的过度生产，从而导致很多自身免疫性疾病 …

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.

The CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. Learn about this gene and related health conditions.

2025年3月26日 · Title: Respiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China. Termination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.

该基因编码的蛋白质在 T 细胞表面表达。 它通过结合 B 细胞表面的 CD40 来调节 B 细胞功能。 该基因的缺陷导致无法进行免疫球蛋白类别转换，并与高 IgM 综合征有关。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface.

The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity.

cd40lg的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的蛋白质的t细胞的表面上表达。它由b细胞表面上的接合cd40调节b细胞的功能。在无力这个基因导致的缺陷接受免疫球蛋白类开关，并与高igm综合征。