CD45 is a type of protein called a tyrosine phosphatase. It plays a critical role in regulating cell signaling pathways that are important for immune cell activation and differentiation. How is CD45 used in pathology?

2025年3月11日 · CD45 is vital in hematological diagnostics, distinguishing leukocyte subsets and identifying malignancies. Since nearly all nucleated hematopoietic cells express CD45, its presence—or absence—guides blood disorder classification. Flow cytometry is the primary tool for assessing CD45 expression, differentiating blasts, lymphocytes, monocytes ...

CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells.

CD45 is a receptor linked protein tyrosine phosphatase present in all cells of the hematopoietic lineage except erythrocytes and plasma cells. Originally known as common leukocyte antigen or protein tyrosine phosphatase receptor type C it was given the designation CD45 by the HCDM.

CD45 is an essential protein on the surface of cells of the haematological and immunological systems. It has been used as a diagnostic tool to identify cells of haematological origin, but its function and structure are not widely understood. This review aims to …

2018年4月1日 · CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and the developmental or activation status of the cell.

2024年12月25日 · PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Immunodeficiency 105, Severe Combined and Immunodeficiency 104, Severe Combined. Among its related pathways are Activation of cAMP-Dependent PKA and Innate Immune System.

CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and …

CD45 activates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts.

CD45 is a major transmembrane glycoprotein expressed on all nucleated hematopoietic cells. Eight isoforms of CD45 are distributed through the immune system according to cell type and degree of cellular differentiation.