2025年1月30日 · CD5 is a transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and some B lymphocytes (B1a).

2023年5月25日 · In a recent study published in Science, He et al. investigated the role of CD5 on dendritic cells (DCs) in priming effector T cells. 1 By proving the importance of CD5 in engaging effective...

2024年12月24日 · CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include Thymic Carcinoma and Prolymphocytic Leukemia. Among its related pathways are Modulators of TCR signaling and T cell activation and Hematopoietic Stem Cells and Lineage-specific Markers.

CD5 is a molecule involved in signal transduction through tyrosine phosphorylation of intracellular proteins. It plays a role in modulating signaling via antigen-specific receptor complexes in T and B lymphocytes, with high expression on mature T-lymphocytes and low expression on a subset of mature B-lymphocytes.

CD5 is a specialized type of protein normally found on the surface of immune cells where it is involved in modulating signal transduction pathways. It plays a significant role in regulating immune responses and maintaining the balance between activating and inhibiting signals within the immune system.

CD5 is a well established negative regulator of TCR and BCR signalling. In the last years, great advances have been made in understanding the molecular mechanisms behind this regulatory function.

2024年6月12日 · CD5 is a critical regulatory molecule in the immune system, involved in modulating T cell and B cell functions, maintaining immune tolerance, and preventing autoimmune responses. Its clinical significance spans autoimmune …

Here we focus on CD5, a transmembrane receptor that regulates T cell functions and development but remains poorly characterized at the molecular level. We will review its roles in physiological conditions and suggest potential molecular effectors that could account for CD5-dependent regulation of TCR signaling.

2018年12月7日 · Here we focus on CD5, a transmembrane receptor that regulates T cell functions and development but remains poorly characterized at the molecular level. We will review its roles in physiological conditions and suggest potential molecular effectors that could account for CD5-dependent regulation of TCR signaling.

CD5, which is a transmembrane glycoprotein expressed on the surfaces of conventional T cells and some B cells, was recently recognized as a marker of a subset of DCs in both mice and humans. CD5 plays an important role in fine-tuning T cell receptor signaling during development and in their effector function in the periphery.