设立分化簇 (CD) 命名系统的目的是对白细胞表面抗原进行分类。 最初，表面抗原是根据与它们结合的对应单克隆抗体进行命名。 随着各实验室逐渐发现抗原常能刺激产生多种单克隆抗体，因此需要采用一种统一的命名系统。 1982 年于巴黎举行的第 1 届国际人类白细胞分化抗原专题讨论会 (HLDA) 上通过了目前使用的命名系统。 根据该命名系统，已经充分表征的抗原将会分配数字（例如，CD1、CD2 等），而对于仅有一种单克隆抗体可以识别的抗原分子，则分配临时名 …

The role of the CD66 antigens in neutrophil effector function was examined using non-cross-reacting and cross-reacting domain-mapped CD66 monoclonal antibody (mAb), which recognize epitopes on biliary glycoprotein (BGP; CD66a), CEA gene family member 6 (CGM6; CD66b), nonspecific cross-reacting antigen 90 (NCA90; CD66c) or CGM1 (CD66d).

CD66b （cluster of differentiation 66，分化簇66b，也称为“癌胚抗原相关细胞黏附分子8”，Carcinoembryonic antigen-related cell adhesion molecule 8，缩写 CEACAM8）是一种细胞表面蛋白质，属于 癌胚抗原 （CEA） 蛋白质家族，通过 糖磷脂酰肌醇 （GPI）锚定在细胞膜上，在 粒细胞 上高表达，可作为粒细胞的 标志物，参与 细胞黏附 、 细胞迁移 和 病原体 识别 [3] 。 ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National …

中性粒细胞占外周血的50-70%，是机体清除细菌感染的主要效应免疫细胞，它对肿瘤的作用主要取决于中性粒细胞所处的环境。 根据 肿瘤微环境 的不同，中性粒细胞（主要的标记为CD66b)可以通过旁分泌促进肿瘤生长功通过抑制肿瘤生长的细胞因子和趋化因子影响肿瘤的进展。 通常认为在 结直肠癌 中， 肿瘤相关中性粒细胞 （toumor-associated neutrophile,TAN )能促进肿瘤的进展和发育，高中性/淋巴（NLR）与肿瘤的不良预后有关。 肿瘤细胞来源的 CXCL5 是缺氧状态下中 …

CD66 and its isoforms modulate several physiologic processes and have a role in aggressiveness of malignancies. We aimed at investigating pan CD66, CD66 a, b, and c expression and their clinical implication in acute leukemia. This study included 85 cases, 50 AML, 33 ALL and 2 mixed lineage leukemia from King Abdullah Medical City, Saudi Arabia.

1996年7月1日 · 癌胚抗原家族的四个成员CD66a，CD66b，CD66c和CD66d在人嗜中性粒细胞上表达。 在嗜中性粒细胞中，这些蛋白质是激活抗原，因为它们的表面表达在刺激后会增加。 为了检查其在嗜中性粒细胞信号传导中的潜在作用，测试了一组特征明确的CD66 mAb对嗜中性粒细胞粘附于人脐静脉内皮细胞的影响。 CD66a，CD66b，CD66c和CD66d抗体各自增加嗜中性粒细胞对人脐静脉内皮细胞单层的粘附。 由CD66抗体引起的嗜中性粒细胞粘附的这种增加被CD18 …

2005年11月16日 · CD66, a member of the carcinoembryonic antigen family, is known to be expressed on cells of myeloid and monocytic origin and has also been demonstrated on blasts from patients with B-lineage acute lymphoblastic leukaemia.

CD66a, CD66b, CD66c, and CD66d antibodies each increased neutrophil adhesion to human umbilical vein endothelial cell monolayers. This increase in neutrophil adhesion caused by CD66 antibodies was blocked by a CD18 antibody and associated with up-regulation of CD11/CD18 on the neutrophil surface.

In conclusion, the CD66b + monocytes represent a novel myeloid subpopulation which is devoid of immune regulatory influences of cancer and displays enhanced proinflammatory capacities. Keywords: Monocyte; Monocyte subtypes; Myeloid-derived suppressor cells (MDSC); Neutrophil; PMN-MDSC; Transcriptomics.

CD66+ cells have previously been identified as a tumor propagating subset in cervical cancers. We investigated the existence, differentiation state and neoplastic potential of CD66+ cells in a pre-cancer cell line harboring HPV31b episomes.