CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155 . CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.

2020年7月1日 · CD96 is a promising candidate for immunotherapy. However, its role and importance in glioma remains unknown. We thus aimed to genetically and clinically characterize CD96 expression in gliomas.

CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor models in a CD8 + T cell-dependent manner.

2024年12月24日 · CD96 (CD96 Molecule) is a Protein Coding gene. Diseases associated with CD96 include C Syndrome and Developmental And Epileptic Encephalopathy 29. Among its related pathways are Innate Immune System and Class I …

CD96 was found to transduce its activating signal through the MEK-ERK pathway. CD96-mediated signaling led to increased frequencies of NUR77- and T-bet-expressing CD8 + T cells and enhanced cytotoxic effector activity, indicating …

2020年3月7日 · A clear understanding of the immune cell populations regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in combination with other existing immune checkpoint blockade therapies.

2024年1月19日 · CD96（Cluster of Differentiation 96）是一种细胞表面蛋白，属于Ig超家族的成员之一。 以下是CD96重组蛋白（艾普蒂生物现货目录号：PA1000-6087）的基本信息： 基因和基因位置： CD96基因位于人类染色体3上，基因名称为CD96。

cd96是制药公司与基因测序公司研发合作模式的一个典型案例，利用基因数据库为药物发现和开发提供新的机会，显示了基因数据库在识别靶标和推进基于人类遗传学新药方面的价值。

2023年1月9日 · Bioinformatics-based analysis of CD96 gene expression in the tissues of patients with hepatocellular carcinoma revealed an increased expression of CD96, suggesting the potential role of CD96 in assisting tumor cells to evade the immune system .

Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T-cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between three receptors fine-tunes immune respo …