CD97 expression in cancer was first reported for dedifferentiated thyroid carcinoma and their lymph node metastases. [39] CD97 is expressed on many types of tumors including thyroid, gastric, pancreatic, esophageal, colorectal, and oral squamous carcinomas as well as glioblastoma and glioblastoma-initiating cells.

2022年2月20日 · CD97信号使cDC2在组织-血液界面上定位，这个位置可以优化抗原捕获，并能对全身性病原体作出非常快速的免疫反应。 CD97在免疫系统和其他组织（包括一些 肿瘤 和发炎组织）中广泛表达，并可能允许其他类型的细胞在流体流动的条件下根据与CD55阳性细胞的相互作用来感知它们的位置。 （生物谷 Bioon.com） Dan Liu et al. CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science, 2022, …

2024年1月15日 · CD97，也被称为ADGRE5，是第一个克隆的人类aGPCR，属于表皮生长因子 (EGF)七跨膜aGPCR家族 (现称为ADGRE家族)。 作为一种原型aGPCR, CD97在N端由3 - 5个EGF样结构域组成，负责配体结合 (CD55等)和细胞粘附相互作用；保守的GAIN结构域对自催化裂解过程至关重要;以及介导下游效应物偶联 (G12 /13蛋白)和信号传导的7跨膜结构域 (TMD)。 值得注意的是，CD97在免疫系统中高度表达，在炎症反应和细胞稳态中起关键调节作用，也与各 …

CD97 (ADGRE5) is an adhesion G protein-coupled receptor (aGPCR) which plays crucial roles in immune system and cancer. However, the mechanism of CD97 activation and the determinant of G 13 coupling selectivity remain unknown. Here, we present the cryo-electron microscopy structures of human CD97 in complex with G 13, G q, and G s. Our ...

2023年7月13日 · cd55和cd97重组蛋白是免疫学中研究配体相互作用、功能特性和发现潜在治疗靶点的重要工具。 Izuhara及其同事使用人CD55重组蛋白进行实验，以确认其对猫抗CD55抗体的特异性。

CD97 is a leucocyte antigen originally recognized on activated human lymphocyte. 1, 2 Activation of lymphocytes by a variety of stimuli rapidly induces the surface expression of CD97. 1, 2 This up-regulation apparently results from a redistribution of preformed CD97 protein as well as from increased mRNA synthesis at the transcriptional level ...

CD97 signaling allows cDC2s to position at the tissue-blood interface, a location that optimizes antigen capture and enables very rapid immune responses to systemic pathogens.

2024年12月4日 · Here, we identify cluster of differentiation 97 (CD97) as an optimal GSC surface antigen for potential targeting by chimeric antigen receptor (CAR) T cell therapy through in vitro antibody screening. CD97 is consistently expressed in all validated patient-derived GSCs and positively correlated with known intracellular GSC markers.

cd97是最早发现的agpcr，属于表皮生长因子亚家族成员，在体内参与多种免疫反应且与多种自身免疫疾病有关。cd97受体在多种恶性肿瘤中高度表达，曾被用作评估肿瘤恶性程度的指标。该受体在肿瘤发展过程中参与调控血管生成。

2009年4月27日 · CD97 is a large heptahelical EGF-TM7 receptor broadly expressed on hematopoietic cells as three isoforms with respectively three, four, or five epidermal growth factor (EGF)-like domains. We here describe the expression characteristics of CD97 on human lymphocyte subsets.