2021年4月21日 · CDNF reportedly promoted recovery in rat models of spinal cord injury and stroke (Zhao et al., 2016; Zhang et al., 2018). Findings. In September 2017, Herantis and Renishaw began a Phase 1/2 study of CDNF and an experimental delivery device in people who have had idiopathic Parkinson’s disease for about a decade.

Huttunen HJ, Saarma M.CDNF Protein Therapy in Parkinson's Disease. Cell Transplant. 2019 Apr;28(4):349-366.Epub 2019 Apr 4 PubMed.

Zhang GL, Wang LH, Liu XY, Zhang YX, Hu MY, Liu L, Fang YY, Mu Y, Zhao Y, Huang SH, Liu T, Wang XJ.Cerebral Dopamine Neurotrophic Factor (CDNF) Has Neuroprotective Effects against Cerebral Ischemia That May Occur through the Endoplasmic Reticulum Stress Pathway.

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease. Brain Behav. 2013 Mar;3(2):75-88. Epub 2013 Jan 14 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.

Tenenbaum L.CDNF: An innovative actor in disease-modifying approaches for Parkinson's disease. Mol Ther. 2021 Sep 1;29(9):2634-2636.

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease. Neuroscience. 2018 Mar 15;374:250-263. Epub 2018 Feb 3 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.

They purified CDNF and after generating polyclonal antibodies discovered the protein in adult mouse heart, skeletal muscle, and testes. They found only low levels in whole brain extracts but immunohistochemical analysis detected CDNF in the CA1 and CA2 region of the hippocampus, the dentate gyrus, the striatum, and the substantia nigra.

Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action. eNeuro. 2017 Jan-Feb;4(1) Epub 2017 Mar 13 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must ...

2015年11月25日 · Find a Therapeutic By Name Go AAB-003 AADvac1 AAV-GAD AAV2-BDNF ABBV-0805 ABBV-552 ABBV-916 ABBV-CLS-7262 ABT 418 ABT-089 ABT-288 ABT-384 ABT-957 ABvac 40 ACD856 Acetyl-l-carnitine HCI ACI-24 ACI-3024 ACI-35 Acitretin ACU193 Aduhelm AF 102B Affitope AD02 Affitope PD01A, PD03A AGB101 AKST4290 AL002 AL003 AL044 …

Kemppainen S, Lindholm P, Galli E, Lahtinen HM, Koivisto H, Hämäläinen E, Saarma M, Tanila H.Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice.