Children's Global Assessment Scale (CGAS)
The Children’s Global Assessment Scale (CGAS), adapted from the Global Assessment Scale for adults, is a rating of general functioning for children and young people aged 4-16 years old.
Secure in family, school, and with peers. There may be transient dificulties and “everyday” worries that occasionally get out of hand (e.g. mild anxiety associated with an important exam, …
Regulation of cGAS–STING signalling and its diversity of cellular ...
2025年1月7日 · In this Review, we describe recent insights from structural studies that have helped to elucidate the molecular mechanisms of the cGAS–STING signalling cascade and we …
The cGAS–STING pathway as a therapeutic target in ... - Nature
2021年4月8日 · Insights into the structural and molecular biology of the cGAS–STING pathway have enabled the development of selective small-molecule inhibitors with the potential to …
CGAS Gene - GeneCards | CGAS Protein | CGAS Antibody
2024年12月24日 · CGAS (Cyclic GMP-AMP Synthase) is a Protein Coding gene. Diseases associated with CGAS include Covid-19 and Severe Covid-19. Among its related pathways …
Regulation and function of the cGAS–STING pathway of
2016年9月20日 · Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates innate immune responses through production of the second messenger cGAMP, …
Cellular functions of cGAS-STING signaling - PubMed
Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic, mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2'3'-cGAMP that mobilizes stimulator of …
清华大学药学院张从刚团队在Nature Reviews Immunology发表cGAS …
最新科研时讯研究背景cGAS-STING信号通路是天然免疫系统的重要组成部分，它的发现回答了免疫学领域的一个重要问题：DNA如何激发天然免疫应答。2024年的拉斯克基础医学奖被授予 …
MAM-STAT3-Driven Mitochondrial Ca+2 Upregulation …
Characterization of MAD iPSC-derived Mesenchymal stem cells (MAD-iMSC) uncovers deregulated mitochondrial Ca +2 as the primary cause of inflammaging, mediated through …
cGAS-STING: mechanisms and therapeutic opportunities
Understanding the mechanisms by which cGAS and STING operate is vital for gaining insights into the biology of this pathway. This review provides a detailed examination of the structural …