Frontiers | Overcoming cold tumors: a combination strategy of …
2024年3月12日 · Strategies that combine ICIs with other treatments such as radiotherapy, chemotherapy, CAR-T cell therapy, or targeted therapy are being investigated to transform ‘cold’ tumors into ‘hot’ ones, potentially increasing the efficacy of ICIs.
Cold and hot tumors: from molecular mechanisms to targeted …
2024年10月18日 · Effective differentiation between “cold” and “hot” tumors, and understanding tumor intrinsic factors, immune characteristics, TME, and external factors are critical for predicting tumor ...
Cold and hot tumors: from molecular mechanisms to targeted …
2024年10月18日 · It is widely accepted that ICB therapy exerts a more profound effect on "hot" tumors, with limited efficacy against "cold" or "altered" tumors, necessitating combinations with other therapeutic modalities to enhance immune cell infiltration into tumor tissue and convert "cold" or "altered" tumors into "hot" ones.
Turning Cold Tumors Into Hot Ones - The ASCO Post
2019年2月10日 · The ASCO Post talked with Dr. Vonderheide about his current research in pancreatic cancer as well as how combining checkpoint inhibitors with radiation therapy and chemotherapy may potentially turn immunologically cold …
Cold Tumors: A Therapeutic Challenge for Immunotherapy
2019年2月7日 · Therapeutic monoclonal antibodies targeting immune checkpoints (ICPs) have changed the treatment landscape of many tumors. However, response rate remains relatively low in most cases. A major factor involved in initial resistance to ICP inhibitors is the lack or paucity of tumor T cell infiltration, characterizing the so-called “cold tumors.”
Immune-based combination therapy to convert immunologically cold tumors …
2022年8月4日 · Numerous therapies, including chemotherapy, radiotherapy, targeted therapy, and anti-angiogenic therapy, all regulate the immune microenvironment and complement immunotherapy for stronger...
Therapeutic strategies to remodel immunologically cold tumors
Here, we propose two broad approaches to convert ‘cold’ tumors into ‘hot’ tumors. The first is to induce immunogenic tumor cell death, through the use of oncolytic viruses or bacteria, conventional cancer therapies (e.g. chemotherapy or radiation therapy) or small molecule drugs.
Cold Tumors: A Therapeutic Challenge for Immunotherapy
2019年2月8日 · In this review, we describe the main mechanisms involved in the absence of T cell infiltration, including lack of tumor antigens, defect in antigen presentation, absence of T cell activation and deficit of homing into the tumor bed. We discuss then the different therapeutic approaches that could turn cold into hot tumors.
Turning tumors from cold to inflamed to improve ... - ScienceDirect
2021年12月1日 · Combining immunotherapy with a range of treatment modalities allow acting on different immune cells and improve immune response in the clinical setting. We review the current strategies to inflame cold tumors that are currently being tested in …
Approaches to treat immune hot, altered and cold tumours with ... - Nature
2019年1月4日 · In this Review, we focus on defining hot, altered and cold tumours, the complexity of the tumour microenvironment, the Immunoscore and immune contexture of tumours, and we describe approaches...