Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. [5] [6] Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. [7]

chk1促进cdc25a的蛋白酶体降解，可以降低cdk（细胞周期蛋白依赖性激酶）活性，抑制细胞周期进程，为dna修复争取时间。 CHK1还通过 BRCA1 、 BRCA2 和RAD51的磷酸化促进HR（同源重组），通过DNA-PK的磷酸化促进NHEJ等。

DNA damage induces activation of Chk1, which then transduces the checkpoint signal and facilitates cell cycle arrest and DNA damage repair. Significant progress has been made recently towards our understanding of Chk1 regulation and its implications in cancer etiology and therapy.

2024年12月24日 · CHEK1 (Checkpoint Kinase 1) is a Protein Coding gene. Diseases associated with CHEK1 include Oocyte/Zygote/Embryo Maturation Arrest 21 and Lynch Syndrome 2. Among its related pathways are HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) and Regulation of activated PAK-2p34 by proteasome mediated degradation.

最新的观点认为CHK1是DNA损伤应答激活的主要标志物，表明CHK1不仅激活了细胞周期检查位点的调节，而且直接影响了DNA修复和细胞凋亡。 因此CHK1在DNA损伤应答机制中的作用能够促进CHK1抑制剂成为放化疗耐受肿瘤患者的一种新的治疗手段。 引用本文: 张瑶, 高晋南. 细胞周期监测点激酶1与DNA损伤应答信号通路在肿瘤中的研究进展 [J] . 肿瘤研究与临床, 2016, 28 (4) : 279-284. DOI: 10.3760/cma.j.issn.1006-9801.2016.04.016. 版权归中华医学会所有。 未经授权，不 …

Originally identified as a mediator of DNA damage response (DDR), checkpoint kinase 1 (Chk1) has a broader role in checkpoint activation in DDR and normal cell cycle regulation. Chk1 activation involves phosphorylation at conserved sites.

2024年6月1日 · CHK1 plays a crucial role in cancer biology as it modulates cell cycle checkpoint activation and DNA repair. Furthermore, a number of other cellular functions of CHK1 are also gradually discovered.

2017年11月22日 · Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression in response to DNA damage. Despite its essential...

Chk1 activation via ATR plays a dominant role in response to replication stresses (the replication checkpoint). Chk1 is also required for amplification of DSB-initiated Cdc25A signaling mediated by ATM/Chk2. Moreover, Chk1 directly phosphorylates essential S-phase kinases (Cdc7 and Tlk1).

2021年1月28日 · A recent study shows that CHK1 is essential for controlling hematopoietic stem and progenitor cell (HSPC) development and expansion; conditional deletion of CHK1 in definitive hematopoietic stem cells caused failure of fetal hematopoiesis and impaired adult hematopoiesis, while, chemical inhibition of CHK1 killed both murine and human HSPCs [26].