2025年1月31日 · By coupling chromatin conformation capture (3C) with PacBio HiFi long-read sequencing, we have developed a new method (CiFi) that enables analysis of genome interactions across repetitive genomic regions with low-input requirements.

2025年3月6日 · CiFi: Accurate long-read chromatin conformation capture with low-input requirements. In this preprint by UC Davis, USDA HI, Sanger UK, and PacBio, researchers find that they can now achieve “haplotype-resolved, chromosome-scale de novo genome assemblies with data from one sequencing technology, and, if desired, from a single sequencing run.”

PacBio highly accurate long-read sequencing provides the most comprehensive view of genomes, transcriptomes, and epigenomes. Learn how SMRT sequencing powers genomic insights in humans, plants, animals and microbes.

By coupling chromatin conformation capture (3C) with PacBio HiFi long-read sequencing, we have developed a new method (CiFi) that enables analysis of genome interactions across repetitive genomic regions with low-input requirements.

PacBio is the only sequencing technology to offer HiFi reads that provide accuracy of 99.9%, on par with short reads and Sanger sequencing. With HiFi reads you no longer compromise long read lengths for high accuracy sequencing to address your …

HiFi Solves brings together the world’s leading clinical genomics researchers to leverage PacBio HiFi sequencing for uncovering the potential causes of genetic diseases that may be difficult to detect with other sequencing methods.

Beyond SMRT Link, which offers a graphic interface to execute fully-developed analysis workflows, PacBio research is constantly innovating with new tools that uncover more from HiFi sequencing. This page highlights some of the popular tools and workflows for HiFi applications.

Targeted sequencing with HiFi reads allows you to sequence only the genomic regions you care about — easily and cost-effectively at scale.

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To maximize HiFi base yield and average read length, it is recommended to start with HMW DNA. If longer HiFi read lengths are required for more degraded samples, pre- or post-library size selection methods may be used. The Agilent Femto Pulse system is highly recommended for accurately measuring the distribution gDNA mass.