Coelenterazine is a luciferin, a molecule that emits light after reaction with oxygen, found in many aquatic organisms across eight phyla. [1] It is the substrate of many luciferases such as Renilla reniformis luciferase (Rluc), Gaussia luciferase (Gluc), and …

2007年2月26日 · applications of coelenterazine are discussed, including its function as a novel antioxidant. Chemiluminescence is the generation of light by a chemical reaction. In most cases, a molecule reacts with oxygen, producing an excited intermediate that emits light as …

2018年6月25日 · Coelenterazine is a luciferin—the most prevalent bioluminescent molecule in sea life. It exists in many marine species, from protozoa to fish. Luciferase enzymes cause coelenterazine to oxidize, which triggers the luminescence.

2001年9月25日 · Here we report that the hydromedusa Aequorea victoria is unable to produce its own coelenterazine and is dependent on a dietary supply of this luciferin for bioluminescence.

Coelenterazine | C26H21N3O3 | CID 135445694 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Coelenterazine was found to be the luciferin in a wide range of bioluminescent marine organisms [14,16,18] such as coelenterates [12,39–52], squid [12,16], shrimp [12,16,53–56], fish [12,15,57–61], and copepods [16], and also in various non-bioluminescent marine organisms [14].

Coelenterazine (CTZ), a luciferin or light-producing compound found in bioluminescent organisms, has sparked great curiosity and interest in searching for analogues with improved photochemical properties.

2013年3月1日 · Coelenterazine is widely distributed in luminous and non-luminous marine organisms [1] and is used as a luciferin (substrate) for a luciferase (enzyme). The luciferase catalyzes the oxidation of coelenterazine to emit blue light (λmax = 460–490 nm) along with the formation of coelenteramide according to the following reaction scheme:

Coelenterazine is the small (~ 400 Da) prosthetic group that binds with apoaequorin to form the active aequorin complex. As coelenterazine is subject to oxidation, it is normally supplied in a sealed vial free of O2. Prior to reconstitution, the coelenterazine should be stored at − 20 °C.

Probes’ offers five derivatives of coelenterazine (C-14260, C-6779, C-6780, C-14261, C-6776) — designated cp, f, h, hcp and n by Shimomura and colleagues 4-6 — that confer different Ca2+ affinities and spectral properties to the aequorin complex (Table 1). Like native coelenterazine, these five derivatives can