2023年11月30日 · 3. It's also key to eat foods that remove excess catachol estrogens from the body and avoid foods and bath products that mimic estrogen.. Excess estrogen slows COMT and COMT is largely responsible ...

Get tested for COMT gene mutation here. What is the COMT Gene and Enzyme? The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. This enzyme is involved in the breakdown of certain neurotransmitters, such as dopamine, epinephrine, and norepinephrine.

Catechol-O-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine).The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM). Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are …

Between 20 and 30 percent of Caucasians of European descent have a COMT mutation. This means that the gene that produces an enzyme to break down certain substances and toxins doesn’t work the way it should, causing a range of health, hormone, and stress-related issues.

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2023年9月28日 · Introduction to COMT Mutations. The realm of genetics is a fascinating field, teeming with potential discoveries that could significantly improve our understanding of human health and disease. One such area of interest is the Catechol-O-methyltransferase (COMT) gene. This gene plays a crucial role in the regulation of several critical bodily functions, and …

2024年10月29日 · Did you know that about 25% of people have a variation of the COMT gene, which influences how their bodies handle stress? This gene helps break down necessary brain chemicals, like dopamine and epinephrine, essential for mood regulation. When mutations like Val158Met happen, they can throw off the balance of essential brain chemicals, possibly …

2024年4月3日 · The COMT gene, also known as catechol-O-methyltransferase, plays a crucial role in the regulation of neurotransmitters in the brain. This gene is involved in the breakdown of catecholamines, including dopamine and norepinephrine, which are essential for …

Other disorders. Variations in the COMT gene also may be associated with mental illness in people without 22q11.2 deletion syndrome. Researchers have looked extensively at the potential connection between changes in the COMT gene and the risk of developing schizophrenia. Most studies have focused on the effects of a particular common variation (polymorphism) in …

2023年2月23日 · What does the COMT enzyme do? COMT (catechol-O-methyltransferase) is a central enzyme that breaks down catecholamines including dopamine, norepinephrine, and epinephrine. COMT plays a vital role in regulating dopamine signaling in the prefrontal cortex where dopamine transporters are relatively sparse.1 Dopamine levels here are critical for …