2022年12月7日 · Here, by integrating in-depth single-cell RNA-sequencing analysis, progenitor lineage labelling and mosaic functional analysis, we report that the diverse yet patterned …

2019年11月18日 · In the mammalian genome, the clustered protocadherin (cPCDH) locus provides a paradigm for stochastic gene expression with the potential to generate a unique …

2022年3月7日 · Clustered protocadherins (cPcdhs) are a large family of cadherin-like proteins named for the clustered arrangement of their genes in vertebrate genomes (Wu and Maniatis, …

该研究首次揭示了细胞表面分子clustered protocadherins (cPCDHs，集簇性原钙粘蛋白)在大脑新皮层兴奋性神经元中的组合表达呈现规律性，并且这种规律性表达调控新皮层神经元的单细胞 …

Here, by integrating in-depth single-cell RNA-sequencing analysis, progenitor lineage labelling and mosaic functional analysis, we report that the diverse yet patterned expression of …

2025年2月16日 · Clustered protocadherins (cPcdhs) belong to the cadherin superfamily and play important roles in neural development. cPcdhs mediate homophilic adhesion and lead to...

In humans, single nucleotide variants scattered across the cPCDH locus have been identified, which associate with multiple neurodevelopmental disorders, including autism and schizophrenia.

该研究首次揭示了细胞表面分子clustered protocadherins（cPCDHs，集簇性原钙粘蛋白）在大脑新皮层兴奋性神经元中的组合表达呈现规律性，并且这种规律性表达调控新皮层神经元的单细 …

2023年5月7日 · 时松海教授团队在Nature发表研究，揭示集簇性原钙粘蛋白 (cPCDH)在大脑新皮层神经元中的规律性表达影响神经元的空间分布和功能环路组装，为理解大脑结构和功能提供 …

2023年12月1日 · Insights from the extraordinary isoform diversity of fly Dscam1, Chelicerata shortened Dscams (sDscams), and vertebrate clustered protocadherins (cPcdhs) as a unique …