Cucurbitacins (Cus) are a class of highly oxidized tetracyclic triterpenoids that confer a bitter taste to cucurbits such as cucumber, melon, watermelon, squash, and pumpkin. To date, a large number of Cus and Cu-derived compounds have been isolated from the Cucurbitaceae family and from other species of the plant (Alghasham, 2013[ 1 ]; Shang ...

Cucurbitacins may be a taste deterrent in plants foraged by some animals and in some edible plants preferred by humans, such as cucumbers and zucchinis. [1] . In laboratory research, cucurbitacins have cytotoxic properties and are under study for …

2022年3月1日 · Cucurbitacin C is associated with foliage and fruit bitterness in cucumber (Shang et al., 2014; Wu et al., 2019). In C. myriocapus and C. africanus , bitterness in both leaves and fruit is caused by accumulation of cucurbitacins A and …

2023年3月30日 · In this study, cucurbitacins A, B, C, D, E, and I and untargeted volatile compounds were analyzed using the fruit of 69 inbred cucumber of diverse cultivars. Only cucurbitacin C was detected in six inbreds. They were classified into four clusters based on the profiles of cucurbitacins and volatile compounds.

2024年5月1日 · Cucurbitacin C (CuC) has been identified as the major cucurbitacin that results in bitter-tasting cucumber (Shang et al., 2014). Humans could perceive bitterness in cucumber even when CuC concentration was less than 0.1 ppm ( Horie et al., 2007 ).

Cucurbitacins are found in many cucurbitaceous plants. They are most common in species of the Bryonia, Cucumis, Cucurbita, Luffa, Echinocystis, Lagenaria and Citrullus. The plants of genera Momordica contain a special group of Cucurbitacins called momordicosides. The level of Cucurbitacins varies between tissues.

Comparative analysis of the Luffa and cucumber genomes showed that Bi, CYP450s, and ACT are located in the conserved syntenic loci, and formed a cucurbitacin biosynthesis cluster. This study provides important insights into major genes and metabolites of the cucurbitacin biosynthetic pathway, deepening the understanding of regulatory mechanisms ...

Cucurbitacins constitute a group of cucumber-derived dietary lipids, highly oxidized tetracyclic triterpenoids, with potential medical uses. These compounds are known to interact with a variety of recognized cellular targets to impede the growth of cancer cells.

The eight most active cucurbitacin components against cancer are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R. Their mechanisms of action include antiproliferation, inhibition of migration and invasion, proapoptosis, and cell cycle arrest promotion.

2023年1月1日 · Cucurbitacin B is the main active component isolated from Cucumis mello L. Research shows that cucurbitacin B exerts powerful anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective and anticancer pharmacological activities through regulating multiple signaling transduction pathways, such as JAK/STAT3, Nrf2 ...