In molecular biology, the CVNH domain (CyanoVirin-N Homology domain) is a conserved protein domain.It is found in the sugar-binding antiviral protein cyanovirin-N (CVN) as well as proteins from filamentous ascomycetes and in the fern Ceratopteris richardii. [1]Cyanovirin-N (CV-N) is an 11-kDa protein from the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several ...

pfam08881 (PSSM ID: 430283): Conserved Protein Domain Family CVNH, CyanoVirin-N Homology domains are found in the sugar-binding antiviral protein cyanovirin-N (CVN) as well as filamentous ascomycetes and in the fern Ceratopteris richardii

Members of the CVNH family are found in a restricted range of eukaryotic organisms as diverse as filamentous ascomycetes and seedless plants. All CVNH proteins so far exhibit a fold that matches the unique fold of the cyanobacterial protein. The CVNH domain is a...

2025年2月14日 · An in vitro anti-HIV screening assay (32) and a SARS-CoV-2 pseudovirus screening assay both aided in the identification of an active agent from the crude aqueous extract (and partially purified fractions) of the tunicate Didemnum molle.Preliminary mass spectrometry indicated that the active constituents were likely proteins. Anti-HIV bioassay guided fractionation using C 4 reversed-phase ...

An anti-HIV screening of natural product extracts resulted in the discovery of a new antiviral protein through bioassay-guided fractionation of an aqueous extract of the ascidian Didemnum molle. The protein was sequenced through a combination of tandem mass spectroscopy and N-terminal Edman degradat …

Cyanovirin-N (CV-N) is a novel protein with broad-spectrum antiviral activity. Its homologs constitute a protein family known as CVNH (Cyanovirin-N homology), which possess the evolutionarily conserved anti-HIV (Human immunodeficiency virus) domain. In this study, more details about the patchy organ …

2008年4月8日 · Solution structures for three members of the recently discovered cyanovirin-N (CV-N) homolog family of lectins have been determined. Cyanovirin-N homologs (CVNHs) from Tuber borchii, Ceratopteris richardii, and Neurospora crassa, representing each of the three phylogenetic groups, were selected.All proteins exhibit the same fold, and the overall structures resemble that of the founding member ...

关键词: 蓝藻抗病毒蛋白-N, 基因复制, 净化选择, 适应性进化, CVNH 基因家族 Abstract: Cyanovirin-N (CV-N) is a novel protein with broad-spectrum antiviral activity. Its homologs constitute a protein family named CVNH (Cyanovirin-N homology), all possessing the evolutionarily conserved anti-HIV (Human immunodeficiency virus) domain.

2011年5月11日 · The rice blast fungus Magnaporthe oryzae's genome encodes a hypothetical protein (MGG_03307) containing a type III CVNH lectin, in which a LysM domain is inserted between individual repeats of a single CVNH domain. At present, no structural or ligand binding data are available for any type III CVNH and functional studies in …

2015年11月3日 · MGG_03307 is a lectin isolated from Magnaporte oryzae, a fungus that causes devastating rice blast disease. Its function is associated with protecting M. oryzae from the host immune response in plants. To provide the structural basis of how MGG_03307 protects the fungus, crystal structures of its CV …