2018年1月2日 · The CXXC domain, first identified as the reader of unmodified CpG dinucleotide, plays important roles in epigenetic regulation by targeting various activities to CpG islands. Here we systematically measured and compared the DNA-binding selectivities of all known human CXXC domains by different bindi …

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene. [5] [6] [7] Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression. [6]

2023年7月10日 · Disruption of Cxxc finger protein 1 (Cxxc1) activity, a key subunit of H3K4 methyltransferase, in ILC3s led to similar aging-related phenotypes. An integrated analysis revealed Kruppel-like...

2018年1月2日 · The CXXC domain, first identified as the reader of unmodified CpG dinucleotide, plays important roles in epigenetic regulation by targeting various activities to CpG islands.

2024年12月24日 · This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and …

2025年2月9日 · CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line. This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain.

2020年4月6日 · Evidence suggests that the CXXC type zinc finger (ZF-CXXC) protein 5 (CXXC5) is a critical regulator/integrator of various signaling pathways that include the estrogen (E2)-estrogen receptor α...

2023年9月21日 · We have unveiled that CFP1 promote lung adenocarcinoma (LUAD) cell proliferation, migration, and invasion while impairing cell apoptosis through in vitro and in vivo models. In addition, high CFP1...

2024年12月24日 · CXXC4 (CXXC Finger Protein 4) is a Protein Coding gene. Diseases associated with CXXC4 include Renal Cell Carcinoma and Severe Congenital Neutropenia . Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Pleural mesothelioma .

2024年12月24日 · CXXC5 (CXXC Finger Protein 5) is a Protein Coding gene. Diseases associated with CXXC5 include Astroblastoma, Mn1-Altered and Central Nervous System Tumor With Bcor Internal Tandem Duplication. Among its related pathways are ESR-mediated signaling and Signal Transduction.