Double homeobox, 4 also known as DUX4 is a protein which in humans is encoded by the DUX4 gene. [3] Its misexpression is the cause of facioscapulohumeral muscular dystrophy (FSHD).

2024年12月24日 · DUX4 (Double Homeobox 4) is a Protein Coding gene. Diseases associated with DUX4 include Facioscapulohumeral Muscular Dystrophy 1 and Soft Tissue Sarcoma. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

双同源异型框4 （英語： Double homeobox, 4，简称DUX4）基因位于 染色体 4q35亚端粒区域的D4Z4重复序列。 D4Z4重复序列的长度具多态性，在第10号染色体也发现类似D4Z4重复序列。 ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of …

Double homeobox 4 (DUX4) encodes for a transcription factor with increasingly important roles in normal physiology and in disease. During the early steps of embryogenesis, DUX4 is involved in the regulation of genes important for pre- and post-implantation development [1, 2, 3].

2020年9月7日 · DUX4 is a highly regulated transcription factor and its expression in skeletal muscle contributes to multiple cellular toxicities and pathologies ultimately leading to muscle weakness and atrophy. Since the discovery of the FSHD candidate gene DUX4, many cell and animal models have been designed for therapeutic approaches and clinical trials ...

2022年3月22日 · Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced human DUX4 expression substantially alters the chromatin accessibility of non-coding DNA and activates thousands of newly identified transcribed enhancer-like regions, preferentially located within ERVL-MaLR repeat elements.

2022年5月1日 · Double homeobox 4 (DUX4) is an early embryonic transcription factor whose expression in the skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). Despite decades of research, our knowledge of FSHD and DUX4 biology is …

Targeting DUX4-mediated toxicity in skeletal muscle was achieved by (1) genetically or epigenetically regulating DUX4 expression, (2) directly targeting DUX4 transcript by RNAi or AOs-based approaches, and (3) inhibiting DUX4 activity.

Double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos. Here we show that induced human DUX4 expression substantially alters the chromatin accessibility of non-coding DNA and activates thousands of newly ...

2017年5月1日 · Here, we present multiple lines of evidence that a eutherian-specific multicopy retrogene, DUX4, encodes a transcription factor that activates hundreds of endogenous genes (for example, ZSCAN4,...