2024年12月24日 · DACT2 (Dishevelled Binding Antagonist Of Beta Catenin 2) is a Protein Coding gene. Diseases associated with DACT2 include Extraocular Retinoblastoma and Retinitis Pigmentosa. Among its related pathways are TGF-beta …

2014年7月14日 · Restoring DACT2 expression in colon cancer cell lines suppressed tumor cell growth by inducing cell apoptosis and inhibiting cell proliferation both in vitro and in vivo. Moreover, DACT2...

2025年2月8日 · DACT2 suppresses hepatocellular carcinoma by inhibiting Wnt signaling in human hepatocellular carcinoma cells. Loss of DACT2 expression is associated with esophageal squamous cell carcinoma. Reduced expression of DACT2 due to methylation-mediated gene silencing promotes hepatocellular carcinoma progression

2015年5月5日 · Restoring DACT2 expression in colon cancer cell lines suppressed tumor cell growth by inducing cell apoptosis and inhibiting cell proliferation both in vitro and in vivo. Moreover, DACT2 overexpression effectively reduced …

Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is involved in Xenopus embryonic development. Human DACT2 is localized on chromosome 6q27, a region of frequent loss of heterozygosity (LOH) in human cancers. However, the function and regulation of DACT2 in human lung cancer remain uncl …

To explore the function and regulation of DACT2 in lung cancer, we analysed genetic and epigenetic changes of DACT2, and determined the potential involvement of this gene as a regulator of Wnt signalling and in lung carcinogenesis.

2024年8月30日 · DACT2 inhibits TGF-β and Wnt signaling pathways by suppressing the phosphorylation of β-catenin on Thr41/Ser45 in HL-1 cells, thereby attenuating the levels of fibrosis.

2017年8月10日 · DACT2, one of the Dact gene family members, was shown to function as a tumor suppressor. However, its function in gliomas remains largely unknown. In this study, we investigated the role of DACT2, underlying molecular mechanisms and …

2013年1月22日 · Dact2 significantly inhibits PITX2 activation of the Dlx2 and amelogenin promoters. Multiple lines of evidence conclude the inhibition is achieved by the physical interaction between Dact2 and Pitx2 proteins. The loss of function of Dact2 also reveals increased cell proliferation due to up-regulated Wnt downstream genes, cyclinD1 and cyclinD2.

2020年3月26日 · Dact2 promotes Dishevelled degradation in the lysosome-dependent pathway and inhibits LEF1 binding to beta-catenin; re-expression of Dact2 stimulates transcriptional activation of T-cell factor-4 and Wnt signaling downstream, which is known to play a gene-suppressive role.