DED is a protein–protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.

DED是 程序性细胞死亡 途径的 衔接子 、 调节子 和 执行子 共享的 蛋白质相互作用 域。 该基因的 过度表达 被证明可诱导微弱的 细胞凋亡。 在刺激作用下，发现该蛋白从 细胞质 易位到 细胞核，并与 UBTF 共定位在 核仁 中，UBTF是RNA聚合酶I转录所需的基础因子。 该基因至少有三种编码相同蛋白质的转录变体。 [8] DEDD已被证明可以与以下基因产生相互作用： ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. …

2024年12月24日 · DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal ... See more...

Gene ID: 9191, updated on 8-Feb-2025. This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.

The CD95 signaling pathway comprises proteins that contain one or two death effector domains (DED), such as FADD/Mort1 or caspase‐8. Here we describe a novel 37 kDa protein, DEDD, that contains an N‐terminal DED. DEDD is highly conserved between human and mouse (98.7% identity) and is ubiquitously expressed.

DEDD, which can bind to FAS-associated death domain (FADD) or caspase-8/10 through DED domains (about eighty amino acid residues), belongs to DED-containing protein family. DEDD can induce apoptosis process in in vitro over-expression studies in mice (Miyazaki and Arai, 2007).

DED 是由程序性细胞死亡途径的适配器、调节器和执行器共享的蛋白质-蛋白质相互作用结构域。 显示该基因的过表达诱导微弱的细胞凋亡。 刺激后，发现这种蛋白质从细胞质转移到细胞核，并与核仁中的 UBTF 共定位，UBTF 是 RNA 聚合酶 I 转录所需的基础因子。 已为该基因发现至少三种编码相同蛋白质的转录变体。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein that contains a death effector domain (DED).

2024年12月10日 · DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.

2001年12月6日 · DEDD is a novel apoptosis signaling molecule that carries an N-terminal DED with complete sequence identity between the murine, rat, bovine and human domains. We previously identified two...

2024年9月19日 · DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis.