2024年5月10日 · Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection.

2024年5月10日 · Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection.

2023年11月4日 · DHZD not only improved the hypothermic symptoms of acute. 42 inflammatory response in macrophages. Similar to that of DXM-treated group, the. 44 lungs were upregulated by DHZD. What’s more, the phagocytic receptor CD36 was. 46 phagocytosis in clathrin- and actin-dependent manner. In short, DHZD is a potential.

2023年11月4日 · Dehydrozaluzanin C-derivative (DHZD) is a modified compound from Magnolia officinalis. Here, we demonstrated that DHZD ameliorated tissue damage (lung, kidney and liver) and excessive inflammatory response induced by LPS challenge or the infection of Carbapenem-resistant Klebsiella pneumoniae (CRKP).

2023年11月1日 · In vitro data suggested that DHZD. PI3K/Akt/p70S6K signaling pathway in macrophages. Interestingly, the combined. played a synergistic role in decreasing IL-6 secretion in sera. Moreover, the. manner. This data suggests that DHZD may be a potential drug candidate for treating. bacterial infections. to infection (1, 2).

宿主定向治疗（HDT）是一种新的辅助策略，可干扰病原体复制或持久性所需的宿主细胞因子。 在这项研究中，我们评估了脱氢扎鲁扎宁 C 衍生物 (DHZD)（脱氢扎鲁扎宁 C (DHZC) 的修饰化合物）作为治疗严重感染的潜在 HDT 药物的效果。 采用LPS诱导的脓毒症小鼠模型和耐碳青霉烯类肺炎克雷伯菌（CRKP）感染小鼠模型进行体内测试。 RAW264.7细胞、小鼠原代巨噬细胞和DC用于体外实验。 地塞米松（DXM）用作阳性对照剂。 DHZD 可改善小鼠 LPS 或 CRKP 感染引起 …

欢迎来到道中道（菏泽）制药有限公司，我们竭诚为您服务！ 道中道（菏泽）药业有限公司是一家蒸蒸日上的新型制药企业，致力于成本优势基础之上的高品质... 菏泽市外专局领导会见公司引进意大利... 道中道（菏泽）制药有限公司获... 道中道（菏泽）制药有限公司再传捷报--两张《药品GMP证书》由山东省... 学习十九大精神 道中道集团党... 随着党的十九大胜利闭幕，10月24日下午，道中道国际控股有限公司党...

一项最新研究表明，一种名为Dehydrozaluzanin C-derivative (DHZD)的化合物可能成为治疗严重感染的新药物。该研究使用小鼠模型和体外实验，评估了DHZD的治疗效果。

2月22日『輕鬆啲』開台 每日2:22 - Post分享 每晚22:22 - 22分鐘日常Live 逢星期四22:22 - 2小時既Live節目 一班好兄弟，逢星期四晚上22:22直播 ...

2023年11月4日 · Dehydrozaluzanin C-derivative (DHZD) is a modified compound from Magnolia officinalis . Here, we demonstrated that DHZD ameliorated tissue damage (lung, kidney and …