Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells.

2024年12月24日 · EGR2 (Early Growth Response 2) is a Protein Coding gene. Diseases associated with EGR2 include Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive and Charcot-Marie-Tooth Disease, Demyelinating, Type 1D. Among its related pathways are Signaling by NTRKs and Transcriptional regulation of white adipocyte differentiation.

早期生长反应蛋白2（英語： Early growth response protein 2 ，EGR-2）是一个由人类基因EGR2编码的蛋白质。 EGR2是一个转录因子，包含三个串联的Cys2His2型锌指结构，该基因的多态性与I型 进行性神经性腓骨肌萎缩症 有关 [ 1 ] 。

Early growth response 2 (EGR2) is a novel regulator of the senescence programme. Bi-allelic mutations in EGR2 cause autosomal recessive demyelinating neuropathy by disrupting the EGR2-NAB complex. NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression.

该基因编码的蛋白质是一个具有三个串联 C2H2 型锌指的转录因子。 该基因的缺陷与 Charcot-Marie-Tooth 病 1D 型 (CMT1D) 、Charcot-Marie-Tooth 病 4E 型 (CMT4E) 和 Dejerine-Sottas 综合征 (DSS) 相关。 已发现该基因编码两种不同亚型的多个转录变体。 [RefSeq 提供，2008 年 10 月] The protein encoded by this gene is a transcription factor …

2023年7月13日 · EGR2 was significantly elevated in myelin-reactive CD4 + T cells from patients with multiple sclerosis and mice with autoimmune neuroinflammation. The EGR2 transcriptional program was...

2020年11月1日 · We identified the TF, early growth response 2 (EGR2), bridging the early transient and late stable gene expression program of polarization. EGR2 is a direct target of IL-4-activated STAT6, having broad action indispensable for 77% of the induced gene signature of alternative polarization, including its autoregulation and a robust, downstream TF ...

在此背景下，2023年2月16日， 南京医科大学 肖明与盛呈雨研究团队在 Nature 子刊 Lab Animal 的封面论文上发文揭示了 早期生长反应因子2（Egr2）通过调控mPFC髓鞘形成，参与幼龄SI小鼠合作行为的建立与维持。 1. 早期SI小鼠的社会交往和合作行为受损. 现有的大鼠和小鼠合作行为范式在某种程度上不足以反映合作行为的内在属性——互相适应和相互促进。 因此， 研究人员建立了一种检测小鼠合作行为的行为学测试平台，可以定量的评估小鼠的合作能力 （bioRxiv …

早期生长反应蛋白2（英语：Early growth response protein 2，EGR-2）是一个由人类 基因 EGR2编码的 蛋白质。 EGR2是一个转录因子，包含三个串联的Cys2His2型锌指结构，该基因的多态性与I型 进行性神经性腓骨肌萎缩症 有关。 EGR2是一种转录因子。

The EGR2 gene, a member of the early growth response gene family, encodes a transcription factor that is a prime regulator of Schwann cell myelination. It may also play a role in hindbrain segmentation and development (summary by Szigeti et al., 2007).