ERK是extracellular regulated protein kinases的英文缩写，指细胞外调节蛋白激酶，包括ERK1和ERK2，是将信号从表面受体传导至细胞核的关键。 许多其他信号通路明显活化时，可活化蛋 …

Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. [5] The protein encoded by this gene is a member of the MAP …

2020年6月23日 · Extracellular signal-regulated kinase 1 (ERK1) and ERK2 relay cell growth and mitogenic signals to multiple substrates, and thus control essential physiological processes.

ERK1/2是 RAF-MEK-ERK信号通路 的关键组成部分，在 Thr202 、 Tyr204 位点被磷酸化从而激活，进而激活多种与细胞增殖、分化、迁移和血管生成相关的底物（超过160种）。 因 …

2025年2月14日 · ERK（Extracellular Regulated Protein Kinases）即细胞外调节蛋白激酶，包括ERK1和ERK2，是将信号从细胞表面受体传导至细胞核的关键激酶。ERK1和ERK2的分子量 …

ERK是一种丝氨酸/苏氨酸蛋白激酶，是一种传递有丝分裂原信号的信号转导蛋白。 ERK通常位于细胞质中；在被激活后，ERK进入细胞核，调节转录因子活性和基因表达。 ERK家族已被证 …

In molecular biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions …

ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this primary structure requirement, many …

In this review we compiled data on ERK1 vs. ERK2 gene structures, protein sequences, expression levels, structural and molecular mechanisms of activation and substrate recognition.

erk是由erk1和erk2两种基因编码的蛋白质组成，它们是p44和p42的主要形式，同时还存在其他可选剪接的亚型。 ERK的激活最终是通过MAPKK对其酪氨酸和苏氨酸残基的磷酸化来完成的。