2024年12月25日 · ETV1 (ETS Variant Transcription Factor 1) is a Protein Coding gene. Diseases associated with ETV1 include Skeletal Ewing Sarcoma and Soft Tissue Sarcoma. Among its related pathways are Akt Signaling and MAPK-Erk Pathway.

该基因编码 ETS (E 二十六) 转录因子家族的成员。 ETS 蛋白调节许多调节生物过程如细胞生长、血管生成、迁移、增殖和分化的靶基因。 所有 ETS 蛋白都包含一个 ETS DNA 结合域，该域与包含共有 5'-CGGA [AT]-3' 的 DNA 序列结合。 由该基因编码的蛋白质除了 C 端区域的 ETS DNA 结合结构域外，还在 N 端区域包含一个保守的短酸性反式激活结构域 (TAD) 。 该基因参与染色体易位，导致多种融合蛋白，包括尤文肉瘤中的 EWS-ETV1 和前列腺癌中的至少 10 个 ETV1 伙 …

2016年10月24日 · ETV1 is a NRG1-responsive factor that is highly expressed in PAM and VCS myocytes, where it establishes the fast conduction phenotype through enrichment of Nkx2-5, Gja5, and Scn5a. Consequently, Etv1 -deficient mice exhibit cardiac conduction defects and developmental abnormalities of the VCS.

2010年10月3日 · Transcriptome profiling and global analyses of ETV1-binding sites suggest that ETV1 is a master regulator of an ICC-GIST-specific transcription network mainly through enhancer binding. The...

etv1 也是潜在的肿瘤标志物，在多种肿瘤中具有辅助诊断和评估预后的临床价值，而靶向 etv1 的策略可能为肿瘤患者带来新的治疗方案。 本文讨论了 ETV1 的激活和促瘤机制，并对 ETV1 作为肿瘤标志物和治疗靶点在临床上的应用进行了总结和展望。

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene. [5] [6]

2019年6月3日 · In this report, we identified SMAD4 as a novel interaction partner of ETV1 that can repress ETV1-mediated transcription, providing a mechanism by which TGF-β signaling may constrain ETV1’s ...

ETV1 and COP1 are a pair of independent predictors of prognosis for triple-negative breast cancer. ETV1 overexpression is associated with prostate cancer aggressiveness. Results show that ETV1 was upregulated at a higher rate in Gastrointestinal stromal tumor and was correlated with KIT expression.

2018年7月2日 · Remarkably, ETV1 induction in human induced pluripotent stem cell-derived cardiomyocytes increases rapid conduction gene expression and inward sodium currents, converting them towards a HPS...

ETV1 is a downstream transcriptional mediator of the MAP kinase pathway and it is tightly regulated by the MAP kinase through transcription, protein stability, and phosphorylation. The endogenous expression of ETV1 is restricted to several tissues, including specific neurons of the central and peripheral nervous systems and the interstitial ...